Cunninghamella bertholletiae Infection in a HLA-Haploidentical Hematopoietic Stem Cell Transplant Recipient with Graft Failure: Case Report and Review of the Literature

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• 作者：Chao Luo ; Jiasheng Wang ; Yongxian Hu ; Yi Luo ; Yamin Tan ; Aiyun Jin…
• 关键词：Cunninghamella ; Mucormycosis ; Stem cell transplantation ; Fungal pneumonia
• 刊名：Mycopathologia
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：181
• 期：9-10
• 页码：753-758
• 全文大小：491 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Medical Microbiology
  Plant Sciences
  Microbial Ecology
  
• 出版者：Springer Netherlands
• ISSN：1573-0832
• 卷排序：181

文摘

Cunninghamella bertholletiae as a rare cause of mucormycosis has been described almost exclusively in immunosuppressed patients such as hematopoietic stem cell transplant (HSCT) recipients. The infection is associated with high rates of mortality despite aggressive treatment. We describe a 40-year-old male with HLA-haploidentical HSCT developed fungal pneumonitis caused by C. bertholletiae complicated by graft failure and prolonged neutropenia. The patient died 102 days after HSCT despite early use of posaconazole and amphotericin B, which are believed to be the two most effective antifungal antibiotics against C. bertholletiae. The case highlights extreme unfavorable outcome in C. bertholletiae infection and neutropenia as a major risk factor.