Increased expression of colony stimulating factor-1 is a predictor of poor prognosis in patients with clear-cell renal cell carcinoma

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• 作者：Liu Yang (1)
  Qian Wu (1)
  Le Xu (2)
  Weijuan Zhang (3)
  Yu Zhu (4)
  Haiou Liu (1)
  Jiejie Xu (1)
  Jianxin Gu (1)
  
  1. Key Laboratory of Glycoconjugate Research ; MOH ; Department of Biochemistry and Molecular Biology ; School of Basic Medical Sciences ; Shanghai Medical College of Fudan University ; Mailbox 103 ; 138 Yixueyuan Road ; Shanghai ; 200032 ; China
  2. Department of Urology ; Zhongshan Hospital ; Fudan University ; Shanghai ; 200032 ; China
  3. Department of Immunology ; School of Basic Medical Sciences ; Shanghai Medical College of Fudan University ; Shanghai ; 200032 ; China
  4. Department of Urology ; Ninth People鈥檚 Hospital ; School of Medicine ; Shanghai Jiaotong University ; Shanghai ; 200011 ; China
  
• 关键词：Clear ; cell renal cell carcinoma ; Colony stimulating factor ; 1 ; Prognostic biomarker ; Recurrence ; free survival ; Cancer ; specific survival
• 刊名：BMC Cancer
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：3,303 KB
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• 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2407

文摘

Background This study aims to evaluate the impact of colony stimulating factor-1 (CSF-1) expression on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery. Methods We retrospectively enrolled 267 patients (195 in the training cohort and 72 in the validation cohort) with ccRCC undergoing nephrectomy at a single institution. Clinicopathologic features, cancer-specific survival (CSS) and recurrence-free survival (RFS) were recorded. CSF-1 levels were assessed by immunohistochemistry in tumor tissues. Kaplan-Meier method was applied to compare survival curves. Cox regression models were used to analyze the impact of prognostic factors on CSS and RFS. Concordance index (C-index) was calculated to assess predictive accuracy. Results In both cohorts, CSF-1 expression positively correlated with advanced Fuhrman grade and necrosis. High CSF-1 expression indicated poor survival and early recurrence of ccRCC patients after surgery, especially those with advanced TNM stage disease. Multivariate Cox regression analysis showed CSF-1 expression was an independent unfavorable prognostic factor for recurrence and survival. The predictive accuracy of the University of California Los Angeles Integrated Staging System (UISS) was significantly improved when CSF-1 expression was incorporated. Conclusions High CSF-1 expression is a potential adverse prognostic biomarker for recurrence and survival of ccRCC patients after nephrectomy.