Minocycline protects against lipopolysaccharide-induced cognitive impairment in mice

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• 作者：Yue Hou ; Guanbo Xie ; Xia Liu ; Guoxun Li ; Congcong Jia ; Jinghua Xu…
• 关键词：Minocycline ; Lipopolysaccharide ; Cognitive impairment ; Microglia ; Astrocytes
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：233
• 期：5
• 页码：905-916
• 全文大小：1,047 KB
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• 作者单位：Yue Hou (1)
  Guanbo Xie (2) (3)
  Xia Liu (1) (3)
  Guoxun Li (1)
  Congcong Jia (1)
  Jinghua Xu (3)
  Bing Wang (1)
  
  1. College of Life and Health Sciences, Northeastern University, 110004, Shenyang, China
  2. The 307th Hospital of Chinese People’s Liberation Army, 100071, Beijing, China
  3. Department of Pharmacology, Shenyang Pharmaceutical University, 110016, Shenyang, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale The role of glial cells, especially microglia and astrocytes, in neuroinflammation and cognition has been studied intensively. Lipopolysaccharide (LPS), a commonly used inducer of neuroinflammation, can cause cognitive impairment. Minocycline is known to possess potent neuroprotective activity, but its effect on LPS-induced cognitive impairment is unknown.