Knockdown of hippocampal cysteinyl leukotriene receptor 1 prevents depressive behavior and neuroinflammation induced by chronic mild stress in mice
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- 作者：Xu-Ben Yu ; Rong-Rong Dong ; Hui Wang ; Jing-Ran Lin ; Yun-Qi An ; Yong Du…
- 关键词：Cysteinyl leukotriene receptor 1 ; Depression ; Chronic mild stress ; Neuroinflammation
- 刊名：Psychopharmacology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：233
- 期：9
- 页码：1739-1749
- 全文大小：633 KB
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Rong-Rong Dong (1)
Hui Wang (2)
Jing-Ran Lin (1)
Yun-Qi An (1)
Yong Du (1)
Su-Su Tang (1)
Mei Hu (1)
Yan Long (1)
Hong-Bin Sun (1)
Ling-Yi Kong (1)
Hao Hong (1)
1. Department of Pharmacology, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China
2. Department of Medical Technology, Taizhou Polytechnic College, Taizhou, 225300, China - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Pharmacology and Toxicology
Psychiatry - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-2072
文摘
Rationale Numerous studies have demonstrated that neuroinflammation is associated with depression-like symptoms and neuropsychological disturbances, and cysteinyl leukotriene receptor 1 (CysLT1R) was reported to be involved in neuroinflammation. The pathophysiological role of CysLT1R has been reported in several types of brain damage. However, the role of CysLT1R in depression remains to be elucidated.