The solubility of cefquinome sulfate in pure and mixed solvents

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• 作者：Rongbao Qi ; Jingkang Wang ; Junxiao Ye…
• 刊名：Frontiers of Chemical Science and Engineering
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：10
• 期：2
• 页码：245-254
• 全文大小：370 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chinese Library of Science
  Industrial Chemistry and Chemical Engineering
  
• 出版者：Higher Education Press, co-published with Springer-Verlag GmbH
• ISSN：2095-0187
• 卷排序：10

文摘

Solid-liquid equilibrium data of cefquinome sulfate is important to develop industrial crystallization processes for cefquinome sulfate. The solubilities of cefquinome sulfate in five pure solvents (methanol, ethanol, ethylene glycol, acetic acid and water) from 277.15 to 305.15 K and in a binary acetone-water solvent from 278.15 to 293.15 K were measured at atmospheric pressure. The pure-solvent solubility data was correlated to the modified Apelblat and Van’t Hoff equations whereas the mixed-solvent system data was correlated to the modified Apelblat, Van’t Hoff, CNIBS/R-K and Jouyban- Acree models. It was found that the solubilities of cefquinome sulfate in all tested solvents decreased with the increasing of temperature. In addition, the thermodynamic properties of the dissolution processes, including standard Gibbs free energy, enthalpy and entropy changes, were calculated using the Van’t Hoff equation. It was found that the dissolution of cefquinome sulfate is exothermic.