Nerve Sprouting Contributes to Increased Severity of Ventricular Tachyarrhythmias by Upregulating iGluRs in Rats with Healed Myocardial Necrotic Injury

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• 作者：Jing Lü (1)
  Xue Gao (1)
  Jingli Gu (1)
  Lan Zhou (1)
  Shu Guo (1)
  Wei Hao (1)
  Zhuan Zhou (2)
  Ji-Min Cao (1)
  
• 关键词：Sympathetic nerve ; Glutamate ; Ionotropic glutamate receptors ; Apoptosis ; Arrhythmia ; Heart
• 刊名：Journal of Molecular Neuroscience
• 出版年：2012
• 出版时间：October 2012
• 年：2012
• 卷：48
• 期：2
• 页码：448-455
• 全文大小：422KB
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• 作者单位：Jing Lü (1)
  Xue Gao (1)
  Jingli Gu (1)
  Lan Zhou (1)
  Shu Guo (1)
  Wei Hao (1)
  Zhuan Zhou (2)
  Ji-Min Cao (1)
  
  1. Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, China
  2. Laboratory of Cellular Biophysics, Institute of Molecular Medicine, Peking University, Beijing, 100871, China
  

文摘

Sympathetic nerve sprouting in healed myocardial infarction (MI) has been associated with high incidences of lethal arrhythmias, but the underlying mechanisms are largely unknown. This study sought to test that sympathetic hyperinnervation and/or MI remodels the myocardial glutamate signaling and ultimately increases the severity of ventricular tachyarrhythmias. Myocardial necrotic injury (MNI) was created by liquid nitrogen freeze–thawing across an intact diaphragm to mimic MI. Cardiac sympathetic hyperinnervation was induced by chronic subcutaneous injection of 4-methylcatechol, a potent stimulator of nerve growth factor expression. The results showed that sympathetic hyperinnervation with or without MNI upregulated the myocardial expression of ionotropic glutamate receptors (iGluRs), including NMDA receptor (NMDAR) and AMPA receptor (AMPAR), and induced cardiomyocyte apoptosis. Intravenous infusion with either NMDA (12?mg/kg) or AMPA (15?mg/kg) triggered ventricular tachycardia and ventricular fibrillation in rats with healed MNI plus sympathetic hyperinnervation; these arrhythmias were prevented by respective antagonist of NMDAR or AMPAR. We conclude that MNI with sympathetic nerve sprouting upregulates the expression of NMDAR and AMPAR in the myocardium and this impact in turn enhances cardiac responses to stimulations of iGluRs and thus increases the incidence of ventricular tachyarrhythmias.