The size matters: regulation of lipid storage by lipid droplet dynamics
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- 作者：Jinhai Yu ; Peng Li
- 关键词：lipid storage ; lipid droplet ; TAG synthesis ; atypical LD fusion ; lipolysis
- 刊名：Science China Life Sciences
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：60
- 期：1
- 页码：46-56
- 全文大小：1286KB
- 刊物主题：Life Sciences, general;
- 出版者：Science China Press
- ISSN：1869-1889
- 卷排序：60
文摘
Adequate energy storage is essential for sustaining healthy life. Lipid droplet (LD) is the subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids under energy deficient conditions. Energy storage capacity of LDs is primarily dependent on the sizes of LDs. Enlargement and growth of LDs is controlled by two molecular pathways: neutral lipid synthesis and atypical LD fusion. Shrinkage of LDs is mediated by the degradation of neutral lipids under energy demanding conditions and is controlled by neutral cytosolic lipases and lysosomal acidic lipases. In this review, we summarize recent progress regarding the regulatory pathways and molecular mechanisms that control the sizes and the energy storage capacity of LDs.