MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis

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• 作者：Wenjia Wang ; Jinhui Li ; Wei Zhu ; Chen Gao ; RuiJingfang Jiang ; Wenxue Li…
• 关键词：miR ; 21 ; Cancer ; Prognosis ; Meta ; analysis
• 刊名：BMC Cancer
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：726 KB
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• 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2407

文摘

Background MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the potential prognostic value of miR-21 in various types of human malignancy remains controversial. The present meta-analysis summarises and analyses the associations between miR-21 status and overall survival (OS) in a variety of tumours. Methods Eligible published studies were identified by searching the PubMed and Chinese Biomedicine databases. The patients-clinical characteristics and survival results were pooled, and a pooled hazard ratio (HR) with 95% confidence intervals (95% CI) was used to calculate the strength of this association. A random-effects model was adopted, and then, meta-regression and subgroup analyses were performed. In addition, an analysis of publication bias was also conducted. Results Twenty-seven eligible articles (including 31 studies) were identified that included survival data for 3273 patients. The pooled HR suggested that high miR-21 was clearly related to worse overall survival (HR--.27, 95% CI: 1.81-2.86), with a heterogeneity measure index of I2--6.0%, p--.001, showing that miR-21 might be a considerable prognostic factor for poor survival in cancer patients. Conclusions MiR-21 might be a potentially useful biomarker for predicting cancer prognosis in future clinical applications.