Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
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- 作者：Fengyun Zhang ; Jinjin Cui ; Xiaojing Liu ; Bo Lv ; Xinxin Liu…
- 刊名：Stem Cell Research & Therapy
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：6
- 期：1
- 全文大小：2,667 KB
- 刊物主题：Stem Cells; Cell Biology;
- 出版者：BioMed Central
- ISSN：1757-6512
文摘
Introduction Mesenchymal stem cell (MSC)-based therapies have had positive outcomes both in animal models of cardiovascular diseases and in clinical patients. However, the number and function of MSCs decline during hypoxia and serum deprivation (H/SD), reducing their ability to contribute to endogenous injury repair. MicroRNA-34a (miR-34a) is originally identified as a TP53-targeted miRNA that modulates cell functions, including apoptosis, proliferation, and senescence via several signaling pathways, and hence is an appealing target for MSC-based therapy for myocardial infarction.