PET and MR imaging of neuroinflammation in hepatic encephalopathy

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• 作者：Yun Yan Su (1)
  Gui Fen Yang (2)
  Guang Ming Lu (1)
  Shawn Wu (3)
  Long Jiang Zhang (1)
  
  1. Department of Medical Imaging ; Jinling Hospital ; Medical School of Nanjing University ; 305 Zhongshan East Road ; Xuanwu District ; Nangjing ; Jiangsu Province ; 210002 ; China
  2. Department of Nuclear Medicine ; Jinling Hospital ; Clinical School of the Medical College ; Nanjing University ; Nanjing ; Jiangsu Province ; 210002 ; China
  3. Medical Imaging Institute of Tianjin ; Tianjin ; 300192 ; China
  
• 关键词：Hepatic encephalopathy ; Neuroinflammation ; Positron emission tomography ; Magnetic resonance imaging ; Molecular imaging ; Reactive oxygen species (ROS)
• 刊名：Metabolic Brain Disease
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：30
• 期：1
• 页码：31-45
• 全文大小：5,663 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  Biochemistry
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7365

文摘

Neurological or psychiatric abnormalities associated with hepatic encephalopathy (HE) range from subclinical findings to coma. HE is commonly accompanied with the accumulation of toxic substances in bloodstream. The toxicity effect of hyperammonemia on astrocyte, such as the alteration in neurotransmission, oxidative stress, astrocyte swelling, is considered as an important factor in the pathogenesis of HE. Besides, neuroinflammation has captured more attention in the process of HE, but the mechanism of neuroinflammation leading to HE remains unclear. Molecular imaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) targeting activated microglia and/ or other mediators appear to be promising noninvasive approaches to assess HE. This review focuses on novel imaging and therapy strategies of neuroinflammation in HE.