Efficacy of electroacupuncture at Zhongliao point (BL33) for mild and moderate benign prostatic hyperplasia: study protocol for a randomized controlled trial

详细信息    查看全文

• 作者：Yang Wang (1)
  Zhishun Liu (1)
  Jinna Yu (1)
  Yulong Ding (1)
  Xuan Liu (1)
  
• 关键词：Electroacupuncture ; Acu ; point Efficacy ; BPH ; RCT
• 刊名：Trials
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：12
• 期：1
• 全文大小：272KB
• 参考文献：1. Linde K, Allais G, Brinkhaus B, / et al.: Acupuncture for migraine prophylaxis. / Cochrane Database Syst Rev 2009 (issue 1).
  2. Linde K, Allais G, Brinkhaus B, / et al.: Acupuncture for tension-type headache. / Cochrane Database Syst Rev 2009 (issue 1).
  3. Ezzo JM, Richardson MA, Vickers A, / et al.: Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. / Cochrane Database Syst Rev 2006 (issue 2).
  4. Campbell A: Point specificity of acupuncture in the light of recent clinical and imaging studies. / ACUPUNCTURE IN MEDICINE 2006,24(3):118鈥?22. CrossRef
  5. Linde K, Streng A, Jurgens S, Hoppe A, Brinkhaus B, Witt C, / et al.: Acupuncture for patients with migraine: a randomized controlled trial. / JAMA 2005,293(17):2118鈥?5. CrossRef
  6. Melchart D, Streng A, Hoppe A, Brinkhaus B, Witt C, Wagenpfeil S, / et al.: Acupuncture in patients with tension-type headache: randomised controlled trial. / BMJ 2005,331(7513):376鈥?2. CrossRef
  7. Witt C, Brinkhaus B, Jena S, Linde K, Streng A, Wagenpfeil S, / et al.: Acupuncture in patients with osteoarthritis of the knee: a randomised trial. / Lancet 2005,366(9480):136鈥?3. CrossRef
  8. Scharf H-P, Mansmann U, Streitberger K, Witte S, Kramer J, Maier C, / et al.: Acupuncture and knee osteoarthritis: a three-armed randomized trial. / Ann Intern Med 2006,145(1):12鈥?0.
  9. Goldman N, Chen M, Fujita T, / et al.: Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. / Nature neuroscience 2010,13(7):883鈥?88. CrossRef
  10. Shuran J, Zhongsuan H: Specific effect of acupuncture at ST36 for visceral pain. / Acupuncture Reaearch 1987, 1:73鈥?6.
  11. Cheng K, Han Y: Study on the Specificity of Effects of Acupuncture of Different Acupoints in Reducing Gentamycin Induced Ototoxicity in Guinea-pigs. / Acupuncture Reaearch 2004,29(3):204鈥?08.
  12. Xu B, Yu X, Chen C, / et al.: Relationship Between Efficacy of Electroacupuncture and Electroacupuncture Stimulation of Different Acupoints and Different Tissue Layers of Acupoint Area in Hypotension plus Bradycardia Rats. / Acupuncture Reaearch 2010,35(6):422鈥?28.
  13. Yang T, Zhang XQ, Feng YW, / et al.: Efficacy of Electroacupuncture in Treating 93 Patients with Benign Prostatic Hyperplasia. / Chinese Journal of Integrated Traditional and Western Medicine 2008,28(11):998鈥?000.
  14. Yang T, Liu Z, Zhang XQ, / et al.: Evaluation on therapeutic effects of electro acupuncture for benign prostatic hyperplasia: A prospective randomized controlled study. / Chinese Journal of Rehabilitation Medicine 2008,23(11):1028鈥?031.
  15. Ding Y, Yu J, Liu Z: A pilot trial of point speciality using electroacupuncture at Zhongliao point for benign prostatic hyperplasia. / Journal of Clinical Acupuncture and Moxibustion, in press.
  16. Chapple CR, Montorsi F, Teuvo TLJ, / et al.: Silodosin therapy for lower urinary tract symptoms in men with Suspected Benign Prostatic Hyperplasia: Results of an International, Randomized, Double-Blind, Placebo- and Active-Controlled Clinical Trial Performed in Europe. / European Urology 2011, 59:342鈥?52. CrossRef
  17. Yu HJ, Lin A, Yang SD, / et al.: Non-inferiority of silodosin to tamsulosin in treating patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). / BJU INTERNATIONAL 2011, doi: 10.1111/j.1464鈥?10X.2011.10233.x.
  18. Wang J: / Clinical Epidemiology-design, measurement and evaluation. 2nd edition. Shanghai: Shanghai Science and Technology Press; 2001:141鈥?42.
  19. Xie H: / Huangdi Neijing. Puslishing House of Ancient chinese medical books; 2001.
  20. Li L, Qin W, Bai L, / et al.: Exploring vision-related acupuncture point specificity with multivoxel pattern analysis. / Magnetic Resonance Imaging 2010,28(3):380鈥?87. CrossRef
  
• 作者单位：Yang Wang (1)
  Zhishun Liu (1)
  Jinna Yu (1)
  Yulong Ding (1)
  Xuan Liu (1)
  
  1. Acupuncture Department, Guang鈥檃nmen Hospital Affiliated to China Academy of Chinese Medical Sciences, No.5 Beixiange Street, Xuanwu District, Beijing, China
  

文摘

Background Acu-point specificity is a key issue in acupuncture. To date there has not been any satisfactory trial which can ratify the specific effect of acupuncture. This trial will evaluate the specific effect of BL33 for mild and moderate benign prostatic hyperplasia (BPH) on the basis of its effectiveness. The non-specific effect will be excluded and the therapeutic effect will be evaluated. Method This is a double-blinded randomized controlled trial. 100 Patients will be randomly allocated into the treatment group (n = 50) and the control group (n = 50). The treatment group receives needling at BL33 and the control group receives needling at non-point. The needling depth, angle, direction, achievement of De Qi and parameters of electroacupuncture are exactly the same in both groups. The primary outcome measure is reduction of international prostate symptom score (IPSS) at the 6th week and the secondary outcome measures are reduction of bladder residual urine, increase in maximum urinary flow rate at the 6th week and reduction of IPSS at the 18th week. Discussion This trial will assess the specific therapeutic effect of electroacupuncture at BL33 for mild and moderate BPH. Trial registration Protocol Registration System of Clinical Trials.gov NCT01218243