Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
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- 作者：Jinqiang Zhu ; Wanshan Song ; Lin Li ; Xiang Fan
- 关键词：Nitric oxide ; Endothelial nitric oxide synthase ; Cerebral blood flow ; Cerebrovascular diseases
- 刊名：Molecular Brain
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：9
- 期：1
- 全文大小：943 KB
- 刊物主题：Neurosciences; Neurology;
- 出版者：BioMed Central
- ISSN：1756-6606
文摘
Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors. Therefore, endothelial nitric oxide synthase (eNOS) becomes a potential therapeutic target for cerebrovascular diseases. This review summarizes the current evidence supporting the importance of CBF to cerebrovascular function, and the roles of NO and eNOS in CBF regulation.