Chronic administration of ketamine mimics the perturbed sense of body ownership associated with schizophrenia

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• 作者：Jinsong Tang ; Hannah L. Morgan ; Yanhui Liao ; Philip R. Corlett…
• 关键词：N ; methyl ; d ; aspartate (NMDA) ; Body ownership ; Rubber hand illusion ; Ketamine ; Psychosis
• 刊名：Psychopharmacology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：232
• 期：9
• 页码：1515-1526
• 全文大小：452 KB
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• 作者单位：Jinsong Tang (1)
  Hannah L. Morgan (2)
  Yanhui Liao (1)
  Philip R. Corlett (3)
  Dong Wang (1)
  Hong Li (1)
  Yanqing Tang (4)
  Jindong Chen (1)
  Tieqiao Liu (1)
  Wei Hao (1)
  Paul C. Fletcher (2)
  Xiaogang Chen (1) (5) (6) (7)
  
  1. Institute of Mental Health, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People’s Republic of China
  2. Department of Psychiatry, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
  3. Department of Psychiatry, Ribicoff Research Facility, Connecticut Mental Health Center, Yale University, New Haven, CT, USA
  4. Department of Psychiatry, The First Affiliated Hospital, China Medical University, 155 Nanjing North Street, Shenyang, Liaoning, 110001, People’s Republic of China
  5. The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, People’s Republic of China
  6. Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, People’s Republic of China
  7. National Technology of Institute of Psychiatry, Central South University, Changsha, Hunan, People’s Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Subanaesthetic ketamine infusion in healthy volunteers induces experiences redolent of early psychosis, including changes in the experience of one’s own body. It is not clear, however, whether repeated self-administration of ketamine has a sustained effect on body representation that is comparable to that found during acute administration. Objectives We sought to establish whether chronic ketamine use resulted in disturbances to sense of body ownership. Methods Following on from our work on the effects of acute ketamine infusion, we used the rubber hand illusion (RHI) to experimentally manipulate the sense of body ownership in chronic ketamine users, compared to healthy controls. Results Chronic ketamine users experienced the RHI more strongly and reported more body-image aberrations, even though they had not recently taken the drug. Conclusions These findings suggest that the chronic ketamine model for psychosis models more long-lasting changes in sense of ownership, perhaps more akin to schizophrenia.