Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis

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• 作者：Xiaohui Liang (1)
  Danying Wang (2)
  Yan Wang (1)
  Zhiqiang Zhou (1)
  Juan Zhang (1)
  Jinsong Li (1)
  
• 关键词：Aurora kinase A ; Aurora kinase B ; Chondrosarcoma
• 刊名：Diagnostic Pathology
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：7
• 期：1
• 全文大小：267KB
• 参考文献：1. Jemal A, Siegel R, Ward E: Caner statistics. / CA Cancer J Clin 2006, 56:106-30. CrossRef
  2. Takayuki I: Aurora kinase as an anti-cancer target. / Cancer letters 2008, 262:1-. CrossRef
  3. Silke L, Yi S, Uta J: Predictive Value of Aurora-A/STK15 Expression for Late Stage Epithelial Ovarian Cancer Patients Treated by Adjuvant Chemotherapy. / Clin Cancer Res 2007, 13:4083-091. CrossRef
  4. Yoshifumi B, Katsuhiko N, Kaori S: Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. / Neoplasia 2009, 11:418-25.
  5. Takayuki I, Yang J, Chie N: Anovel treatment strategy targeting Aurora Kinases in acute myelogenous leukemia. / Mol Cancer Ther 2007, 6:1851-857. CrossRef
  6. Qi GY, Ogawa I, Kudo Y: Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer. / Virchows Arch 2007, 450:297-02. CrossRef
  7. Barbara V, Joost J, Oudejans : Frequent overexpression of aurora B kinase, a novel drug target, in non-small eell lung carcinoma patients. / Mol Cancer Ther 2006, 5:2905-913. CrossRef
  8. Arihiro A, Shinji T, Mahmut Y: The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma. / J Hepatol 2010, 52:63-1. CrossRef
  9. Hiroshi K, Subrata S: Aurora kinase inhibitors as anticancer molecules. / Biochim Biophys Acta 2010, 1799:829-39. CrossRef
  10. David B, Jos B, Jan S: Clinical experience with aurora kinase inhibitors:a Review. / Oncologist 2009, 14:780-93. CrossRef
  11. Gengyin Z, Peng G: The derivative of molecular pathology——the inevitable development track of the pathology. / Journal of Shandong University(Health Sciences) 2011, 49:63-6.
  12. Zhifu W, Zhiyan L: Throat chondrosarcomas: 2 cases report. / Journal of Shandong University(Health Sciences) 2003, 41:96-7.
  13. Marco LI, Valentina M, Silvia S: Aurora kinase a expression is associated with lung cancer histological-subtypes and with tumor de-differentiation. / J Transl Med 2011, 9:100-06. CrossRef
  14. Rudolf R, Peter G, Uta J: Aurora kinase a messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma. / Clin Cancer Res 2006, 12:5136-141. CrossRef
  15. Wang XX, Liu R, Jin SQ: Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell line. / Cell Res 2006, 16:356-66. CrossRef
  16. Tehatehou S, Wirtenberger M, Hernnlinki K: Aurora Kinase A and B and familial breast cancer risk. / Cancer Lett 2007, 247:266-72. CrossRef
  17. Ikezoe T, Yang J, Nishioka C: A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia. / Mol Cancer Ther 2007, 6:1851-857. CrossRef
  18. Lirong R, Minglin L, Lan X: Effect of RNAi targeting Aurora B on the paclitaxel chemosensitivity in ovary cancer cell line A2780. / Acta Medicinae Universitatis Scientiae et Technologiae Huazhong 2011, 40:651-55.
  19. Giannis M, Evangelos T, Meletios-Athanassios D: Aurora kinase as targets for cancer therapy. / Cancer Treat Rev 2008, 34:175-82. CrossRef
  
• 作者单位：Xiaohui Liang (1)
  Danying Wang (2)
  Yan Wang (1)
  Zhiqiang Zhou (1)
  Juan Zhang (1)
  Jinsong Li (1)
  
  1. Department of Pathology, Qilu Hospital of Shandong University, Jinan, 250012, China
  2. Department of Admission office, Qilu Hospital of Shandong University, Jinan, 250012, China
  

文摘

Purpose To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy. Methods To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up. Results The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (p<0.01). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (p<0.05), but not age and gender (p>0.05). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (p<0.01). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (p<0.01). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (p<0.05) and Aurora Kinase A expression was an independent risk marker of survival(HR=11.263, 95%CI: 2.317-4.748, P=0.003). Conclusion Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma. Virtual Slide The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.