Association study of the miRNA-binding site polymorphisms of CDKN2A/B genes with gestational diabetes mellitus susceptibility

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• 作者：Xiaojing Wang ; Wei Li ; Liangkun Ma ; Jinsong Gao ; Juntao Liu ; Fan Ping…
• 关键词：CDKN2A/B ; miR ; binding SNP ; Gestational diabetes mellitus
• 刊名：Acta Diabetologica
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：52
• 期：5
• 页码：951-958
• 全文大小：369 KB
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• 作者单位：Xiaojing Wang (1)
  Wei Li (1)
  Liangkun Ma (2)
  Jinsong Gao (2)
  Juntao Liu (2)
  Fan Ping (1)
  Min Nie (1)
  
  1. Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuai Fu Yuan No. 1, Dongcheng District, Beijing, 100730, China
  2. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Diabetes
  Metabolic Diseases
  
• 出版者：Springer Milan
• ISSN：1432-5233

文摘

Aims Gestational diabetes mellitus (GDM) is a complex disease induced by a combination of genetic factors and environmental exposures. Growing evidence suggests that common single nucleotide polymorphisms within miRNA-binding sites (miR-binding SNPs) contribute to the development of various diseases. However, the roles of miR-binding SNPs in GDM have not been fully elucidated. The CDKN2A/B genes have been identified as two of the strongest genetic determinants for diabetes risk. The aim of the study was to first investigate the associations between miR-binding SNPs of CDKN2A/B, GDM susceptibility, and quantitative metabolism traits.