Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer’s disease

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• 作者：Li Wu ; Jiasi Wang ; Nan Gao ; Jinsong Ren ; Andong Zhao ; Xiaogang Qu
• 关键词：drug delivery ; graphene ; mesoporous silica ; Alzheimer’s disease ; amyloid β ; peptides
• 刊名：Nano Research
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：8
• 期：7
• 页码：2400-2414
• 全文大小：4,626 KB
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• 作者单位：Li Wu (1) (2)
  Jiasi Wang (1) (2)
  Nan Gao (1)
  Jinsong Ren (1)
  Andong Zhao (1) (2)
  Xiaogang Qu (1)
  
  1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China
  2. University of Chinese Academy of Sciences, Beijing, 100039, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chinese Library of Science
  Chemistry
  Nanotechnology
  
• 出版者：Tsinghua University Press, co-published with Springer-Verlag GmbH
• ISSN：1998-0000

文摘

Metal ions are involved in Aβ aggregate deposition and neurotoxicity via various processes, including acceleration of Aβ aggregation, disruption of normal metal homeostasis, and formation of reactive oxygen species (ROS). Although metal chelation is a promising therapeutic strategy for Alzheimer’s disease (AD), the widespread use of chelation therapy faces a significant problem; namely, it is difficult to differentiate toxic metals associated with Aβ plaques from those required by normal metal homeostasis. Furthermore, the multifactorial nature of AD and the current lack of an accepted unitary theory to account for AD neurodegeneration also restrict AD treatment through a single therapeutic strategy. This paper presents a novel bifunctional platform by integrating nonpharmacological and pharmacological cues into one system for AD treatment. This electrically responsive drug release platform, based on conducting polymer polypyrrole (PPy) incorporated with graphene-mesoporous silica nanohybrids (GSN) nanoreserviors, could realize on-demand controlled drug delivery with spatial and temporal control. Electrochemical stimulation can treat peripheral nerve injury (PNI) to stimulate neurite outgrowth. This novel system can also effectively inhibit Aβ aggregate formation, decrease cellular ROS, and protect cells from Aβ-related toxicity. The purpose of this research is to promote the design of noninvasive remote-controlled multifunctional systems for AD treatment.