Significance of rosiglitazone inhibiting TLR4 expression in partial hepatic ischemia/reperfusion of mice
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- 作者：Dongsheng Zhai (1) (3)
Jinxiang Zhang (2)
Qichang Zheng (1)
Zhengliang Li (1)
Jinhui Zhang (1)
Yuan Tian (1) - 关键词：hepatic reperfusion injury ; toll ; like receptor ; rosiglitazone ; peroxisome proliferator ; activated receptor γ
- 刊名：Journal of Huazhong University of Science and Technology [Medical Sciences]
- 出版年：2008
- 出版时间：October 2008
- 年：2008
- 卷：28
- 期：5
- 页码：564-567
- 全文大小：361KB
- 参考文献：1. Constantino F, Ronald W B, Jerzy W K / et al. Hepatic ischemia/reperfusion injury—a fresh look. Exp Mol Pathol, 2003,74:86 CrossRef
2. Nakajima A, Wada K, Miki H / et al. Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology, 2001, 120: 460-69 CrossRef
3. Lawlor D K, Brock R W, Harrls K A / et al. Cytokines contribute to early hepatic parenchymal injury and microvascular dysfuntion after bilateral hind limb ischemia. J Vasc Surg, 1999,30(4):533-41 CrossRef
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10. Cuzzocrea S, Pisano B, Dugo L / et al. Rosiglitazone and 5-deoxy-delta12, 14-preostaglandinJ2, ligand of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischemia/reperfusion injury of the gut. Br J Pharmacol, 2003,140:366-76 CrossRef
11. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol, 2003,21:335-76 CrossRef
12. Zhai Y, Shen X D, O’Connell R / et al. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent Pathway. J Immunol, 2004,173:7115-119
13. Appel S, Mirakaj V, Bringmann A / et al. PPAR-γ agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-κB pathways. Blood, 2005,106:3888-894 CrossRef - 作者单位：Dongsheng Zhai (1) (3)
Jinxiang Zhang (2)
Qichang Zheng (1)
Zhengliang Li (1)
Jinhui Zhang (1)
Yuan Tian (1)
1. Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
3. Department of General Surgery, Affiliated Hospital of Hubei Institute for Nationalities, Enshi, 445000, China
2. Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
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