miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression
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  • 作者：Rui Chu (1) (2)
    Guangquan Mo (1) (2)
    Zhijun Duan (1) (2)
    Mei Huang (2)
    Jiuyang Chang (4)
    Xiaodong Li (1) (3)
    Pixu Liu (1) (3)

    1. The First Affiliated Hospital Collaborative Innovation Center of Oncology-Institute of Cancer Stem Cell     ; Dalian Medical University ; Dalian ; 116011 ; China
    2. Department of Gastroenterology     ; The First Affiliated Hospital of Dalian Medical University ; Dalian ; 116011 ; China
    4. Department of Anesthesiology     ; Dalian Medical University ; Dalian ; 116044 ; China
    3. Institute of Cancer Stem Cell     ; Dalian Medical University ; Cancer Center ; Dalian ; 116044 ; China
  • 关键词：miRNA ; miRNA biogenesis ; Hepatocellular carcinoma ; Molecular mechanism
  • 刊名：Cell Communication and Signaling
  • 出版年：2014
  • 出版时间：December 2014
  • 年：2014
  • 卷：12
  • 期：1
  • 全文大小：1,336 KB
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  • 刊物主题：Cell Biology; Protein-Ligand Interactions; Receptors; Cytokines and Growth Factors;
  • 出版者：BioMed Central
  • ISSN：1478-811X
文摘
The pathogenesis of hepatocellular carcinoma (HCC) is not fully understood, which has affected the early diagnosis and treatment of HCC and the survival time of patients. MicroRNAs (miRNAs) are a class of evolutionarily conserved small, non-coding RNAs, which regulate the expression of various genes post-transcriptionally. Emerging evidence indicates that the key enzymes involved in the miRNA biosynthesis pathway and some tumor-specific miRNAs are widely deregulated or upregulated in HCC and closely associated with the occurrence and development of various cancers, including HCC. Early studies have shown that miRNAs have critical roles in HCC progression by targeting many critical protein-coding genes, thereby contributing to the promotion of cell proliferation; the avoidance of apoptosis, inducing via angiogenesis; and the activation of invasion and metastasis pathways. Experimental data indicate that discovery of increasing numbers of aberrantly expressed miRNAs has opened up a new field for investigating the molecular mechanism of HCC progression. In this review, we describe the current knowledge about the roles and validated targets of miRNAs in the above pathways that are known to be hallmarks of HCC, and we also describe the influence of genetic variations in miRNA biosynthesis and genes.

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