Mass transfer enhancement and surface functionalization in digital microfluidics using AC electrowetting: the smaller, the better

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• 作者：Johannes Theisen ; Laurent Davoust
• 关键词：Drop ; Mixing ; Diffusion ; Stuart layer ; Biosensors ; Biofouling
• 刊名：Microfluidics and Nanofluidics
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：18
• 期：5-6
• 页码：1373-1389
• 全文大小：3,792 KB
• 参考文献：Batchelor GK (1967) An introduction to fluid mechanics. Cambridge University Press, Cambridge
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  Ramos
• 作者单位：Johannes Theisen (1)
  Laurent Davoust (2)
  
  1. LEGI, Microfluidics, Particles and Interfaces (MIP) Laboratory, Université Grenoble Alpes, 38000, Grenoble, France
  2. SIMaP, Electromagnetic Processing of Materials (EPM) Laboratory, Grenoble Institute of Technology (Grenoble-INP) / CNRS / Université Grenoble Alpes, 38402, Saint Martin d’Hères, France
  
• 刊物类别：Engineering
• 刊物主题：Engineering Fluid Dynamics
  Medical Microbiology
  Polymer Sciences
  Nanotechnology
  Mechanics, Fluids and Thermodynamics
  Engineering Thermodynamics and Transport Phenomena
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1613-4990

文摘

This paper addresses modelling and computation of stirring and chemical transport at drop scale due to shape oscillations of small amplitude induced by coplanar AC electrowetting on dielectrics (EWOD). An axisymmetric flow inside a drop deformed by standing capillary waves is promoted by coplanar EWOD in the oscillating regime (\(\omega \sim\) 10-00?Hz). This can be seen as a new stirring/mixing mechanism at microscale provided that a deformable fluid interface is available. The latter requirement is fully satisfied in biomedical applications of digital microfluidics where droplets of volume ~1?μL are commonly handled. A steady streaming model at large Strouhal number is taken into account in order to investigate time-dependent chemical transport in a sessile drop under oscillating EWOD. Numerical calculations based on finite element method are performed to predict the transport of a biochemical solute with possible affinity for drop surface and supporting solid surface as well. A dedicated weak form is also derived to take into account diffusional transport along the liquid surface. Mass transfer enhancement is investigated by considering the variance of the chemical concentration in the transient regime. Special attention is given to investigate mass transfers and surface ageing by considering the respective roles of the Thiele number, the Damk?hler number, the Peclet and Surface Peclet numbers.