Gut Microbiota and Autism: Key Concepts and Findings

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• 作者：Helen T. Ding ; Ying Taur ; John T. Walkup
• 关键词：Autism ; Autism spectrum disorder (ASD) ; Regressive autism ; Gastrointestinal symptoms ; Microbiota ; Microbiome
• 刊名：Journal of Autism and Developmental Disorders
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：47
• 期：2
• 页码：480-489
• 全文大小：
• 刊物类别：Behavioral Science
• 刊物主题：Child and School Psychology; Pediatrics; Neurosciences; Public Health;
• 出版者：Springer US
• ISSN：1573-3432
• 卷排序：47

文摘

There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms.