Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study
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- 作者：Chris J Packard (1)
Vladimir Bezlyak (2)
Jennifer S McLean (3)
G David Batty (11) (12) (4)
Ian Ford (2)
Harry Burns (5)
Jonathan Cavanagh (6)
Kevin A Deans (13) (7)
Marion Henderson (8)
Agnes McGinty (1)
Keith Millar (6)
Naveed Sattar (9)
Paul G Shiels (10)
Yoga N Velupillai (3)
Carol Tannahill (3) - 刊名：BMC Public Health
- 出版年：2011
- 出版时间：December 2011
- 年：2011
- 卷：11
- 期：1
- 全文大小：321KB
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65. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/11/42/prepub - 作者单位：Chris J Packard (1)
Vladimir Bezlyak (2)
Jennifer S McLean (3)
G David Batty (11) (12) (4)
Ian Ford (2)
Harry Burns (5)
Jonathan Cavanagh (6)
Kevin A Deans (13) (7)
Marion Henderson (8)
Agnes McGinty (1)
Keith Millar (6)
Naveed Sattar (9)
Paul G Shiels (10)
Yoga N Velupillai (3)
Carol Tannahill (3)
1. Glasgow Clinical Research Facility, Tennent Building, 38 Church Street, Western Infirmary, G11 6NT, Glasgow, UK
2. Robertson Centre for Biostatistics, University of Glasgow, Level 11, Boyd Orr Building, University Avenue, G12 8QQ, Glasgow, UK
3. Glasgow Centre for Population Health, 1st Floor, House 6, 94 Elmbank Street, G2 4DL, Glasgow, UK
11. Centre for Cognitive Ageing & Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
12. The George Institute for International Health, Sydney, Australia
4. Medical Research Council Social and Public Health Sciences Unit, 4 Lilybank Gardens, Glasgow, G12 8RZ, UK
5. Scottish Government, St. Andrew鈥檚 House, Regent Road, EH1 3DG, Edinburgh, UK
6. College of Medical, Veterinary and Life Sciences, University of Glasgow: Psychological Medicine, Gartnavel Royal Hospital, 1055 Great Western Road, G12 0XH, Glasgow, UK
13. Department of Clinical Biochemistry, Aberdeen Royal Infirmary, First Floor, Link Building, Foresterhill, Aberdeen, AB25 2ZD, UK
7. Department of Clinical Biochemistry, NHS Greater Glasgow & Clyde, Glasgow Royal Infirmary, Macewen Building, 84 Castle Street, Glasgow, G4 0SF, UK
8. Medical Research Council Social and Public Health Sciences Unit, 4 Lilybank Gardens, G12 8RZ, Glasgow, UK
9. Division of Cardiovascular and Medical Sciences, based at Vascular Biochemistry, University of Glasgow, 4th Floor, Queen Elizabeth Building, Glasgow Royal Infirmary, 10 Alexandra Parade, G31 2E, Glasgow, UK
10. Faculty of Medicine, University Department of Surgery, University of Glasgow, Level 2, Queen Elizabeth Building, Glasgow Royal Infirmary, 10 Alexandra Parade, G31 2ER, Glasgow, UK - ISSN：1471-2458
文摘
Background Socioeconomic gradients in health persist despite public health campaigns and improvements in healthcare. The Psychosocial and Biological Determinants of Ill-health (pSoBid) study was designed to uncover novel biomarkers of chronic disease that may help explain pathways between socioeconomic adversity and poorer physical and mental health. Methods We examined links between indicators of early life adversity, possible intermediary phenotypes, and markers of ill health in adult subjects (n = 666) recruited from affluent and deprived areas. Classical and novel risk factors for chronic disease (lung function and atherosclerosis) and for cognitive performance were assessed, and associations sought with early life variables including conditions in the parental home, family size and leg length. Results Associations were observed between father's occupation, childhood home status (owner-occupier; overcrowding) and biomarkers of chronic inflammation and endothelial activation in adults (C reactive protein, interleukin 6, intercellular adhesion molecule; P < 0.0001) but not number of siblings and leg length. Lung function (forced expiratory volume in 1 second) and cognition (Choice Reaction Time, the Stroop test, Auditory Verbal Learning Test) were likewise related to early life conditions (P < 0.001). In multivariate models inclusion of inflammatory variables reduced the impact and independence of early life conditions on lung function and measures of cognitive ability. Including variables of adult socioeconomic status attenuated the early life associations with disease biomarkers. Conclusions Adverse levels of biomarkers of ill health in adults appear to be influenced by father's occupation and childhood home conditions. Chronic inflammation and endothelial activation may in part act as intermediary phenotypes in this complex relationship. Reducing the 'health divide' requires that these life course determinants are taken into account.