Intracoronary Imaging in the Detection of Vulnerable Plaques
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- 作者：Jonathan A. Batty ; Shristy Subba ; Peter Luke…
- 关键词：Interventional cardiology ; Imaging ; Coronary artery disease ; Intravascular ultrasonography ; Near ; infrared spectroscopy ; Optical coherence tomography
- 刊名：Current Cardiology Reports
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：18
- 期：3
- 全文大小：907 KB
- 刊物主题：Cardiology;
- 出版者：Springer US
- ISSN：1534-3170
文摘
Coronary artery disease is the result of atherosclerotic changes to the coronary arterial wall, comprising endothelial dysfunction, vascular inflammation and deposition of lipid-rich macrophage foam cells. Certain high-risk atherosclerotic plaques are vulnerable to disruption, leading to rupture, thrombosis and the clinical sequelae of acute coronary syndrome. Though recognised as the gold standard for evaluating the presence, distribution and severity of atherosclerotic lesions, invasive coronary angiography is incapable of identifying non-stenotic, vulnerable plaques that are responsible for adverse cardiovascular events. The recognition of such limitations has impelled the development of intracoronary imaging technologies, including intravascular ultrasound, optical coherence tomography and near-infrared spectroscopy, which enable the detailed evaluation of the coronary wall and atherosclerotic plaques in clinical practice. This review discusses the present status of invasive imaging technologies; summarises up-to-date, evidence-based clinical guidelines; and addresses questions that remain unanswered with regard to the future of intracoronary plaque imaging.