Recent advances in the pharmacologic treatment of spinal cord injury

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• 作者：April Cox (1)
  Abhay Varma (2)
  Naren Banik (1)
  
  1. Department of Neurosciences ; Medical University of South Carolina ; 96 Jonathan Lucas ST. MSC606 ; Charleston ; SC ; 29425 ; USA
  2. Department of Neurosurgery ; Medical University of South Carolina ; 96 Jonathan Lucas ST. MSC606 ; Charleston ; SC ; 29425 ; USA
  
• 关键词：Spinal cord injury ; Neurodegeneration ; Inflammation ; Estrogen ; Regeneration ; Myelin
• 刊名：Metabolic Brain Disease
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：30
• 期：2
• 页码：473-482
• 全文大小：423 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  Biochemistry
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7365

文摘

A need exists for the effective treatment of individuals suffering from spinal cord injury (SCI). Recent advances in the understanding of the pathophysiological mechanisms occurring in SCI have resulted in an expansion of new therapeutic targets. This review summarizes both preclinical and clinical findings investigating the mechanisms and cognate pharmacologic therapeutics targeted to modulate hypoxia, ischemia, excitotoxicity, inflammation, apoptosis, epigenetic alterations, myelin regeneration and scar remodeling. Successful modulation of these targets has been demonstrated in both preclinical and clinical studies with agents such as Oxycyte, Minocycline, Riluzole, Premarin, Cethrin, and ATI-355. The translation of these agents into clinical studies highlights the progress the field has made in the past decade. SCI proves to be a complex condition; the numerous pathophysiological mechanisms occurring at varying time points suggests that a single agent approach to the treatment of SCI may not be optimal. As the field continues to mature, the hope is that the knowledge gained from these studies will be applied to the development of an effective multi-pronged treatment strategy for SCI.