Influence of orientation and area of the extended cortical current source on the magnetoencephalography (MEG) inverse problem

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• 作者：Jong-Ho Choi (1)
  Feng Luan (1) (2)
  Min-Hyuk Kim (1)
  Hyun-Kyo Jung (1)
  Chang-Hwan Im (3)
  
• 关键词：Distributed source model ; Magnetoencephalography (MEG) ; Neuroelectromagnetic inverse problem ; Source imaging
• 刊名：Biomedical Engineering Letters
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：2
• 期：2
• 页码：124-128
• 全文大小：467KB
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• 作者单位：Jong-Ho Choi (1)
  Feng Luan (1) (2)
  Min-Hyuk Kim (1)
  Hyun-Kyo Jung (1)
  Chang-Hwan Im (3)
  
  1. School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Korea
  2. School of Information Science and Engineering, Northeastern University, Shenyang, China
  3. Department of Biomedical Engineering, Hanyang University, Seoul, Korea
  
• ISSN：2093-985X

文摘

Purpose In this paper, we investigated the influence of orientation and activation area of extended cortical current sources upon the solutions of magnetoencephalography (MEG) inverse problems. Methods Extensive simulation studies were performed with artificial MEG datasets generated using a realistic head geometry model. Results Our simulation studies demonstrated that as the source activation area was extended beyond a threshold level, the radial component of cortical sources was weakened and thus the accuracy of MEG inverse problem was enhanced. Conclusions These are important findings suggesting that one may not need to be concerned too much about the insensitivity of MEG to radial sources in many practical MEG measurements.