Study of myoblast differentiation using multi-dimensional scaffolds consisting of nano and micropatterns
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- 作者：Sung Ho Cha ; Hyun Jong Lee ; Won-Gun Koh
- 关键词：Myogenesis ; Multi ; dimensional scaffold ; Topographical cue ; Electrospun alignment ; Poly(ethylene glycol) hydrogel pattern
- 刊名：Biomaterials Research
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：21
- 期：1
- 全文大小：1571KB
- 刊物类别：Biomaterials;
- 刊物主题：Biomaterials;
- 出版者：BioMed Central
- ISSN：2055-7124
- 卷排序：21
文摘
BackgroundThe topographical cue is major influence on skeletal muscle cell culture because the structure is highly organized and consists of long parallel bundles of multinucleated myotubes that are formed by differentiation and fusion of myoblast satellite cells. In this technical report, we fabricated a multiscale scaffold using electrospinning and poly (ethylene glycol) (PEG) hydrogel micropatterns to monitor the cell behaviors on nano- and micro-alignment combined scaffolds with different combinations of angles.