Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonica

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• 作者：Kyoung Hwangbo (1)
  Ming Shan Zheng (1) (2)
  Young-Jin Kim (1)
  Jong-Yeop Im (3)
  Chong-Soon Lee (3)
  Mi-Hee Woo (4)
  Yurngdong Jahng (1)
  Hyun-Wook Chang (1)
  Jong-Keun Son (1)
  
• 关键词：Reynoutria japonica ; Polygonaceae ; Topoisomerase ; Cytotoxicity
• 刊名：Archives of Pharmacal Research
• 出版年：2012
• 出版时间：September 2012
• 年：2012
• 卷：35
• 期：9
• 页码：1583-1589
• 全文大小：543KB
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• 作者单位：Kyoung Hwangbo (1)
  Ming Shan Zheng (1) (2)
  Young-Jin Kim (1)
  Jong-Yeop Im (3)
  Chong-Soon Lee (3)
  Mi-Hee Woo (4)
  Yurngdong Jahng (1)
  Hyun-Wook Chang (1)
  Jong-Keun Son (1)
  
  1. College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea
  2. College of Pharmacy, Yanbian University, Yanji, 133000, China
  3. School of Biotechnology, Yeungnam University, Gyongsan, 712-749, Korea
  4. College of Pharmacy, Catholic University of Daegu, Gyeongsan, 712-702, Korea
  
• ISSN：1976-3786

文摘

Three anthraquinones (1, 2 and 4), three stilbenes (5, 6 and 7) and 3,5-dihydroxybenzyl alcohol (3) were isolated from Reynoutria japonica. Their structures were identified as emodin (1), emodin-8-O-β-d-glucoside (2), 3,5-dihydroxybenzyl alcohol (3), citreorosein (4), cis-resveratrol (5), trans-resveratrol (6) and trans-resveratrol-5-O-β-d-glucopyranoside (7) by comparing their physicochemical and spectral data with published data. Compound 3 was isolated for the first time from the Polygonaceae family. Among the purified compounds, 3 showed more potent inhibitory activity against topoisomerase I (IC50: 4 μM) than camptothecin, as the positive control (IC50: 18 μM). Compounds 3, 4, 5, 6 and 7 showed stronger inhibitory activities toward DNA topoisomerase II (IC50: 0.54, 14, 15, 0.77 and 3 μM, respectively) than the positive control, etoposide (IC50: 44 μM). Compounds 1 and 4 displayed weak cytotoxicities against human lung cancer (A549), ovarian cancer (SK-OV-3), human liver hepatoblastoma (HepG2) and colon adenocarcinoma (HT-29) cell lines.