Intubation time required for tracheal intubation with low-dose rocuronium in children with and without atropine

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• 作者：Hyun Jeong Kwak (1)
  Sang Kee Min (2)
  Bong Ki Moon (2)
  Kyung Cheon Lee (1)
  Yong Beom Kim (1)
  Jong Yeop Kim (2)
  
• 关键词：Atropine ; Low ; dose rocuronium ; Intubation
• 刊名：Journal of Anesthesia
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：27
• 期：2
• 页码：199-204
• 全文大小：203 KB
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• 作者单位：Hyun Jeong Kwak (1)
  Sang Kee Min (2)
  Bong Ki Moon (2)
  Kyung Cheon Lee (1)
  Yong Beom Kim (1)
  Jong Yeop Kim (2)
  
  1. Department of Anesthesiology and Pain Medicine, Gachon University Gil Medical Center, Incheon, Korea
  2. Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, Korea
  
• ISSN：1438-8359

文摘

Purpose The purpose of this study was to determine the intubation time needed to facilitate tracheal intubation (TimeEI) with a low dose of rocuronium (0.3?mg/kg) during propofol induction, and to determine whether this time was reduced by the administration of atropine. Methods Forty-six children, aged 3-0?years, were randomly assigned to receive either saline (control group) or atropine 10?μg/kg (atropine group). Anesthesia was induced with alfentanil 10?μg/kg, propofol 2.5?mg/kg, and rocuronium 0.3?mg/kg. Each TimeEI at which tracheal intubation was attempted was predetermined according to the up-and-down method. The values of TimeEI that provided excellent intubation conditions in 50 and 95?% of patients were defined as TimeEI50 and TimeEI95, respectively. Results TimeEI50?±?SD was 160?±?26.2 and 150?±?13.7?s in the control and atropine groups, respectively. Using isotonic regression, TimeEI95 in the control and atropine groups was 199?s (95?% CI 198.8-00.7?s) and 171?s (95?% CI 171.3-72.1?s), respectively. TimeEI95 was significantly higher in the control group than in the atropine group (P?<?0.001). HR was significantly higher in the atropine group than in the control group during the study period. Conclusions This study demonstrated that the TimeEI95 of a low dose of rocuronium (0.3?mg/kg) required for excellent tracheal intubation was 199?s during i.v. anesthesia induction using propofol and alfentanil in children. Also, i.v. atropine (10?μg/kg) before anesthesia induction was able to reduce TimeEI95 by 28?s.