Anti-inflammatory Effect of Tanshinone I in Neuroprotection Against Cerebral Ischemia–Reperfusion Injury in the Gerbil Hippocampus
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- 作者：Joon Ha Park (1)
Ok kyu Park (2)
Jeong-Hwi Cho (1)
Bai Hui Chen (3)
In Hye Kim (1)
Ji Hyeon Ahn (1)
Jae-Chul Lee (1)
Bing Chun Yan (4)
Ki-Yeon Yoo (5)
Choong Hyun Lee (6)
In Koo Hwang (7)
Seung-Hae Kwon (2)
Yun Lyul Lee (3)
Moo-Ho Won (1)
Jung Hoon Choi (8) - 关键词：Transient global cerebral ischemia ; Tanshinone I ; CA1 pyramidal neuron ; Neuroprotection ; Pro ; inflammatory cytokines ; Anti ; inflammatory cytokines
- 刊名：Neurochemical Research
- 出版年：2014
- 出版时间：July 2014
- 年：2014
- 卷：39
- 期：7
- 页码：1300-1312
- 全文大小：4,559 KB
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Ok kyu Park (2)
Jeong-Hwi Cho (1)
Bai Hui Chen (3)
In Hye Kim (1)
Ji Hyeon Ahn (1)
Jae-Chul Lee (1)
Bing Chun Yan (4)
Ki-Yeon Yoo (5)
Choong Hyun Lee (6)
In Koo Hwang (7)
Seung-Hae Kwon (2)
Yun Lyul Lee (3)
Moo-Ho Won (1)
Jung Hoon Choi (8)
1. Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea
2. Division of Analytical Bio-imaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, 200-701, South Korea
3. Department of Physiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea
4. Institute of Integrative Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, 225001, China
5. Department of Oral Anatomy, College of Dentistry and Research Institute of Oral Science, Gangneung-Wonju National University, Gangneung, 210-702, South Korea
6. Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, 330-714, South Korea
7. Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea
8. Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, 200-701, South Korea - ISSN：1573-6903
文摘
Tanshinone I (TsI) is an important lipophilic diterpene extracted from Danshen (Radix Salvia miltiorrhizae) and has been used in Asia for the treatment of cerebrovascular diseases such as ischemic stroke. In this study, we examined the neuroprotective effect of TsI against ischemic damage and its neuroprotective mechanism in the gerbil hippocampal CA1 region (CA1) induced by 5?min of transient global cerebral ischemia. Pre-treatment with TsI protected pyramidal neurons from ischemic damage in the stratum pyramidale (SP) of the CA1 after ischemia–reperfusion. The pre-treatment with TsI increased the immunoreactivities and protein levels of anti-inflammatory cytokines [interleukin (IL)-4 and IL-13] in the TsI-treated-sham-operated-groups compared with those in the vehicle-treated-sham-operated-groups; however, the treatment did not increase the immunoreactivities and protein levels of pro-inflammatory cytokines (IL-2 and tumor necrosis factor-α). On the other hand, in the TsI-treated-ischemia-operated-groups, the immunoreactivities and protein levels of all the cytokines were maintained in the SP of the CA1 after transient cerebral ischemia. In addition, we examined that IL-4 injection into the lateral ventricle did not protect pyramidal neurons from ischemic damage. In conclusion, these findings indicate that the pre-treatment with TsI can protect against ischemia-induced neuronal death in the CA1 via the increase or maintenance of endogenous inflammatory cytokines, and exogenous IL-4 does not protect against ischemic damage.