Impact of the HIV Tat C30C31S dicysteine substitution on neuropsychological function in patients with clade C disease
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- 作者：Robert H. Paul (1)
John A. Joska (2)
Carol Woods (3)
Soraya Seedat (4)
Susan Engelbrecht (5)
Jacqueline Hoare (2)
Jodi Heaps (1)
Victor Valcour (6)
Beau Ances (7)
Laurie M. Baker (1)
Lauren E. Salminen (1)
Dan J. Stein (2) - 关键词：HIV ; Clade C ; Tat protein ; C31S dicysteine motif ; Cognitive performance
- 刊名：Journal of NeuroVirology
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：20
- 期：6
- 页码：627-635
- 全文大小：340 KB
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John A. Joska (2)
Carol Woods (3)
Soraya Seedat (4)
Susan Engelbrecht (5)
Jacqueline Hoare (2)
Jodi Heaps (1)
Victor Valcour (6)
Beau Ances (7)
Laurie M. Baker (1)
Lauren E. Salminen (1)
Dan J. Stein (2)
1. Department of Psychology and Behavioral Neuroscience, University of Missouri-St. Louis, University Boulevard, St. Louis, USA
2. MRC Unit on Anxiety & Stress Disorders, Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa
3. Department of Psychology, University of Kansas, Kansas, KS, USA
4. MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa
5. Division of Medical Virology, Stellenbosch University and National Health Laboratory Services (NHLS), Cape Town, South Africa
6. Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
7. Department of Neurology, Washington University Medical School, St. Louis, MO, USA - ISSN：1538-2443
文摘
Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cognitive impairment. To date, no study has specifically examined cognitive function in clade C-infected patients as a function of the presence or absence of the Tat C31 substitution. The present study investigated the impact of the Tat C30C31S genetic substitution among individuals residing in South Africa infected with clade C HIV that either exhibited the C30C31 motif (n--28) or the C31S motif (n--6). A control group of seronegative individuals was included to examine the overall impact of HIV on cognitive performance. All individuals completed a comprehensive neuropsychological battery consisting of tests sensitive to HIV. Results revealed that clade C-infected individuals performed significantly worse across cognitive tests compared to seronegative controls. However, there were no significant differences in cognitive performances between individuals with the C31S motif versus those without the C31S substitution. Proximal CD4 cell count and plasma viral load were unrelated to cognitive performances for either group. Results confirm that the C31S dicysteine motif substitution of the Tat protein does not appreciably moderate neuropsychological outcomes in clade C. Further, these findings highlight the importance of clinical management of cognitive symptoms among individuals infected with this viral clade worldwide.