Epidemiologic characterization of 30 confirmed cases of human infection with avian influenza A(H7N9) virus in Hangzhou, China

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• 作者：Hua Ding (1)
  Li Xie (1)
  Zhou Sun (1)
  Qing-Jun Kao (1)
  Ren-Jie Huang (1)
  Xu-Hui Yang (1)
  Chun-ping Huang (1)
  Yuan-Yuan Wen (1)
  Jing-Cao Pan (1)
  Xiao-Ying Pu (1)
  Tao Jin (2)
  Xiao-Hong Zhou (3)
  Lin Zheng (4)
  Jian Li (5)
  Feng-Juan Wang (6)
  
• 关键词：Human avian influenza ; H7N9 subtype ; Epidemiologic characteristics ; External environmental detection
• 刊名：BMC Infectious Diseases
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：384 KB
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• 作者单位：Hua Ding (1)
  Li Xie (1)
  Zhou Sun (1)
  Qing-Jun Kao (1)
  Ren-Jie Huang (1)
  Xu-Hui Yang (1)
  Chun-ping Huang (1)
  Yuan-Yuan Wen (1)
  Jing-Cao Pan (1)
  Xiao-Ying Pu (1)
  Tao Jin (2)
  Xiao-Hong Zhou (3)
  Lin Zheng (4)
  Jian Li (5)
  Feng-Juan Wang (6)
  
  1. Hangzhou Center for Disease Control and Prevention, Hangzhou, 310021, China
  2. Shangcheng District Center for Disease Control and Prevention, Hangzhou, 310009, China
  3. Xiacheng District Center for Disease Control and Prevention, Hangzhou, 310003, China
  4. Xihu District Center for Disease Control and Prevention, Hangzhou, 300013, China
  5. Jianggan District Center for Disease Control and Prevention, Hangzhou, 310004, China
  6. Xiaoshan District Center for Disease Control and Prevention, Hangzhou, 311201, China
  
• ISSN：1471-2334

文摘

Background We examined the clinical and epidemiological characteristics of 30 cases of human infection with avian influenza A(H7N9) virus in Hangzhou and investigated their external environments to provide evidence for contact tracing and disease prevention and control. Methods The cases confirmed from April 1 through May 1, 2013 were studied. Field epidemiologic surveys were conducted to collect the clinical and epidemiologic data. Case-related and environmental specimens were collected for etiologic detection. Results Thirty cases of human infection with avian influenza A(H7N9) virus were confirmed in Hangzhou from April 1 through May 1, 2013, including one pregnant woman and three deaths. The median age of the patients was 62?years (range: 38-6?years). Twenty-three of the patients were men (76.67%). The median duration between disease onset and occurrence of respiratory failure and confirmed diagnosis was 5 and 6?days, respectively. Maximum medical observation of 666 close contacts of the patients revealed no irregularity. Of 314 external environmental specimens, the overall positive detection rate of H7N9 nucleic acid was 28.98%. Eight districts of Hangzhou city had positive detections in the external environments, the highest rate being in Yuhang District (78.13%). Statistical analysis of the specimen collection locations indicates a significant difference between the case-linked locations and the non-case locations (χ 2 --6.563, p-lt;-.05) in terms of H7N9 viral nucleic acid detection rate. No epidemiologic link has been found among the 30 cases. Conclusions Most of the infected were retired individuals aged 60?years or older. Men made the majority. The cases are sporadic at present, with no evidence of human-to-human transmission. Exposures to poultry and live poultry markets may be important sources of infection.