Ginsenoside Rd Improves Learning and Memory Ability in APP Transgenic Mice

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• 作者：Juanfang Liu ; Xiaodong Yan ; Ling Li ; Yuan Li…
• 关键词：Alzheimer’s disease ; Ginsenoside Rd ; APP transgenic mice ; Inflammatory reaction
• 刊名：Journal of Molecular Neuroscience
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：57
• 期：4
• 页码：522-528
• 全文大小：1,078 KB
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• 作者单位：Juanfang Liu (1) (2)
  Xiaodong Yan (3)
  Ling Li (4)
  Yuan Li (5)
  Linfu Zhou (1)
  Xiaohui Zhang (1)
  Xinghua Hu (6)
  Gang Zhao (1)
  
  1. Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China
  2. Department of Clinical Aerospace Medicine, Fourth Military Medical University, Xi’an, 710032, China
  3. Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710032, China
  4. Department of Geriatrics, Shaanxi Provincial TCM Hospital, Xi’an, 710003, China
  5. Second Medical School of Southern Medical University, Guangzhou, 510515, China
  6. Department of Endocrinology, Shaanxi Provincial TCM Hospital, Xi’an, 710003, China
  
• 刊物主题：Neurosciences; Neurochemistry; Cell Biology; Proteomics; Neurology;
• 出版者：Springer US
• ISSN：1559-1166

文摘

Alzheimer’s disease (AD) is a complicated neurodegenerative disease which causes memory loss and dementia. Many researchers have revealed the vital roles of β-amyloid proteins (Aβ) in the proceeds of AD. Aβ deposition in AD patients-brains might function as immune stimulus, and inflammation is believed to play an important role in AD pathologically. We experimentally used amyloid β-protein precursor (APP) transgenic (Tg) mice in this study to further clarify the neuroprotective effects of ginsenoside Rd on AD and its possible mechanisms. It was found that Rd could improve learning and memory ability in APP Tg mice, probably through inhibiting the transcription activity of NFκB. With the activation of the NFκB pathway being suppressed, the reduction of pro-inflammatory cytokines and the generation of protective factors had been increased ultimately. In conclusion, Rd had a neuroprotective effect on APP Tg mice, and it can be used as an alternative drug therapy in AD patients for their memory dysfunction. Keywords Alzheimer’s disease Ginsenoside Rd APP transgenic mice Inflammatory reaction