Interleukin-10 Regulated Gene Expression in Cells of Hypothalamic-Pituitary-Adrenal Axis Origin
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- 作者：Huolin Tu ; Peter L. Rady ; Terry Juelich ; Stephen K. Tyring ; Nina Koldzic-Zivanovic ; Eric M. Smith and Thomas K. Hughes
- 关键词：KEY WORDS ; interleukin ; 10 ; hypothalamic ; pituitary ; adrenal axis ; microarray ; gene expression
- 刊名：Cellular and Molecular Neurobiology
- 出版年：2007
- 出版时间：February, 2007
- 年：2007
- 卷：27
- 期：2
- 页码：161-170
- 全文大小：165 KB
文摘
1. Aim: The hypothalamic-pituitary-adrenal (HPA) axis is a mediator for interactions between the immune and neuroendocrine systems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) have been shown to activate the HPA axis. Recently, interleukin-10, an important anti-inflammatory cytokine in the immune system, has been shown to be expressed in the central nervous system and neuroendocrine system. Little is known, however, about IL-10’s functions in the HPA axis. 2. Methods: The Affymetrix DNA microarray (mouse genome U74Av2 Probe Array) was conducted to determine the gene expression profile regulated by IL-10 in cells of HPA axis origin.