Obesity Modulates the Immune Response to Oxidized LDL in Hypertensive Patients

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• 作者：Henrique Andrade R. Fonseca (1)
  Francisco A. Fonseca (1) (3)
  Andrea M. Monteiro (2) (3)
  Henrique T. Bianco (1)
  Paulo Boschcov (4)
  Sergio A. Brando (1)
  Luiz Juliano (4)
  Magnus Gidlund (2) (5)
  Maria C. Izar (1) (3)
  
• 关键词：Autoantibodies ; Oxidized LDL ; Inflammation ; Body mass index ; Hypertension
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：67
• 期：3
• 页码：1451-1460
• 全文大小：
• 作者单位：Henrique Andrade R. Fonseca (1)
  Francisco A. Fonseca (1) (3)
  Andrea M. Monteiro (2) (3)
  Henrique T. Bianco (1)
  Paulo Boschcov (4)
  Sergio A. Brando (1)
  Luiz Juliano (4)
  Magnus Gidlund (2) (5)
  Maria C. Izar (1) (3)
  
  1. Cardiology Division, Department of Medicine, Federal University of Sao Paulo, Rua Pedro de Toledo, 276, Sao Paulo, SP, 04039030, Brazil
  3. National Institute of Complex Fluids, Sao Paulo, SP, Brazil
  2. Department of Immunology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, SP, Brazil
  4. Department of Biophysics, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
  5. National Institute of Nanomaterials for Integrated Markers, Recife, PE, Brazil
  
• ISSN：1559-0283

文摘

Obesity and hypertension have been recognized as inflammatory diseases capable of activating the immune system, thus contributing to an increased cardiovascular risk. However, the link between adaptive immunity, obesity, and hypertension is poorly understood. We investigated the relationship of the body mass index (BMI) on the inflammatory, vascular, and immune responses in patients with hypertension nave of anti-hypertensive treatment. Hypertensive patients (N=88) were divided into three groups: normal weight (NW), overweight (OW), and obese (OB) subjects. Anti-oxidized LDL autoantibodies (anti-oxLDL Abs), anti-ApoB-D peptide (anti-ApoB-D) Abs, interleukin (IL)-8 and IL-10, flow-mediated dilation (FMD) of the brachial artery, and 24-h ambulatory blood pressure monitoring (ABPM) were assessed. OB patients presented lower levels of anti-oxLDL Abs and IL-10, higher levels of IL-8, and impaired FMD, when compared to NW and OW (P<0.05), without differences between groups regarding anti-ApoB-D Abs. After adjusting for age, systolic and diastolic blood pressure, anti-oxLDL Abs were inversely correlated with BMI and waist circumference (r=0.24, P=0.02 and r=0.25, P=0.02, respectively), whereas ApoB-D correlated with 24-h ABPM (r=0.22, P=0.05 for systolic, and r=0.29, P=0.01 for diastolic blood pressure). Regression analyses showed inverse associations of anti-oxLDL Abs with BMI (=0.05, P=0.01) and waist circumference (=0.01, P=0.02); anti-ApoB-D Abs were associated with systolic and diastolic 24-h ABPM (=0.96, P=0.04; =1.02, P=0.005, for systolic and diastolic 24-h ABPM, respectively). Among hypertensive patients, obesity modulates the immune and inflammatory milieu, determining an unfavorable balance of cytokines and reduction in titers of anti-oxLDL Abs. Twenty-four hour ABPM is associated with titers of anti-ApoB-D Abs.