Association Between Hepatitis B Viral Burden in Chronic Infection and a Functional Single Nucleotide Polymorphism of the PDCD1 Gene
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- 作者：Linghua Zheng ; Dongling Li ; Fusheng Wang ; Hao Wu ; Xiaozhu Li ; Junliang Fu ; Xinyue Chen ; Lizhong Wang ; Yang Liu and Shengdian Wang
- 关键词：PD ; 1 ; single ; nucleotide polymorphism ; hepatitis B virus ; viral load
- 刊名：Journal of Clinical Immunology
- 出版年：2010
- 出版时间：November 2010
- 年：2010
- 卷：30
- 期：6
- 页码：855-860
- 全文大小：172.0 KB
文摘
Background PD-1, encoded by PDCD1, is highly expressed on virus-specific T cells and plays critical roles in modulating anti-virus immune responses in chronic viral infection. It is unknown, however, whether polymorphisms of the PDCD1 are associated with viral clearance during chronic viral infections.