Primary medulla oblongata germinomas: two case reports and review of the literature

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• 作者：Shuyu Hao (5)
  Da Li (5)
  Jie Feng (6)
  Liang Wang (5)
  Zhen Wu (5)
  Junting Zhang (5)
  Liwei Zhang (5)
  
• 关键词：Germinoma ; Medulla oblongata ; Treatment
• 刊名：World Journal of Surgical Oncology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：11
• 期：1
• 全文大小：521 KB
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• 作者单位：Shuyu Hao (5)
  Da Li (5)
  Jie Feng (6)
  Liang Wang (5)
  Zhen Wu (5)
  Junting Zhang (5)
  Liwei Zhang (5)
  
  5. Department Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, NO.6 Tiantan Xili Dongcheng district, Beijing, 100050, P R China
  6. Beijing Neurosurgical Institute, Capital Medical University, NO.6 Tiantan Xili Dongcheng district, Beijing, 100050, P R China
  
• ISSN：1477-7819

文摘

An intracranial germinoma is a tumor that is sensitive to radiotherapy. As medulla oblongata germinomas are extremely rare, determining an accurate preoperative diagnosis is challenging. Two cases of medulla oblongata lesions were surgically treated, and a postoperative diagnosis of germinoma was determined in both of the cases. The tumor in one patient completely resolved after a treatment course consisting of surgical intervention, radiotherapy and chemotherapy; the other patient, who did not receive any type of adjuvant treatment after surgery, suffered from tumor relapse and died from pneumonia 8 months following surgery. A preoperative diagnosis of medulla oblongata germinoma is difficult because of the lack of specific clinical signs and symptoms. If the correct diagnosis is reached, patients can have a favorable prognosis with proper evaluation and treatment. An invasive operation can potentially lesion and impair the function of the medulla oblongata, which is fatal to the patient.