Nesfatin-1 Decreases Excitability of Dopaminergic Neurons in the Substantia Nigra

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• 作者：Chen Li (2)
  Fang Zhang (2)
  Limin Shi (1)
  Haoyun Zhang (1)
  Zibin Tian (1)
  Junxia Xie (1)
  Hong Jiang (1)
  
• 关键词：Nesfatin ; 1 ; Substantia nigra ; Dopaminergic neurons ; Excitability
• 刊名：Journal of Molecular Neuroscience
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：52
• 期：3
• 页码：419-424
• 全文大小：359 KB
• 作者单位：Chen Li (2)
  Fang Zhang (2)
  Limin Shi (1)
  Haoyun Zhang (1)
  Zibin Tian (1)
  Junxia Xie (1)
  Hong Jiang (1)
  
  2. Department of Pharmacology, Medical College of Qingdao University, Qingdao, 266021, China
  1. Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, 266071, China
  
• ISSN：1559-1166

文摘

Nesfatin-1, a newly discovered satiety molecule which reduces feeding behavior, has been recognized as a unique regulatory neuropeptide with its multiple roles, both central and peripheral. However, whether it had neuronal modulation effect on dopaminergic neurons is largely unknown. In the present study, using whole-cell patch clamp under current-clamp mode, we investigate the effects of nesfatin-1 on the electrical activity of rat nigral dopaminergic neurons. Nesfatin-1 could produce a resting membrane potential hyperpolarization on the majority of dopaminergic neurons tested. The spike frequency decreased by 23.13?±-.93 and 43.20?±-.56?% in 5-nM and 10-nM nesfatin-1 groups, respectively. These effects persisted in the presence of ionotropic glutamate and GABA receptor antagonists. Our study suggests that nesfatin-1 postsynaptically inhibits the electrical activity of nigral dopaminergic neurons.