Early atherosclerosis and cardiac autonomic responses to mental stress: a population-based study of the moderating influence of impaired endothelial function

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• 作者：Nadja Chumaeva (1) (2)
  Mirka Hintsanen (1)
  Taina Hintsa (1)
  Niklas Ravaja (3)
  Markus Juonala (4)
  Olli T Raitakari (4) (5)
  Liisa Keltikangas-J?rvinen (1)
  
• 刊名：BMC Cardiovascular Disorders
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：10
• 期：1
• 全文大小：539KB
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  50. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2261/10/16/prepub
  
• 作者单位：Nadja Chumaeva (1) (2)
  Mirka Hintsanen (1)
  Taina Hintsa (1)
  Niklas Ravaja (3)
  Markus Juonala (4)
  Olli T Raitakari (4) (5)
  Liisa Keltikangas-J?rvinen (1)
  
  1. Institute of Behavioural Sciences, University of Helsinki, P.O. Box 9, FIN-00014 Helsinki, Finland
  2. Division of Medical Problems of Cell Biology, Institute of Cell Biophysics, Institutional Street 3, Pushchino, Moscow region, 142290, Russia
  3. Center for Knowledge and Innovation Research, Helsinki School of Economics, P.O. Box 1210, 00101, Helsinki, Finland
  4. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinanmyllynkatu 10, 20520, Turku, Finland
  5. Department of Clinical Physiology, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland
  

文摘

Background Acute mental stress may contribute to the cardiovascular disease progression via autonomic nervous system controlled negative effects on the endothelium. The joint effects of stress-induced sympathetic or parasympathetic activity and endothelial function on atherosclerosis development have not been investigated. The present study aims to examine the interactive effect of acute mental stress-induced cardiac reactivity/recovery and endothelial function on the prevalence of carotid atherosclerosis. Methods Participants were 81 healthy young adults aged 24-39 years. Preclinical atherosclerosis was assessed by carotid intima-media thickness (IMT) and endothelial function was measured as flow-mediated dilatation (FMD) using ultrasound techniques. We also measured heart rate, respiratory sinus arrhythmia (RSA), and pre-ejection period (PEP) in response to the mental arithmetic and speech tasks. Results We found a significant interaction of FMD and cardiac RSA recovery for IMT (p = 0.037), and a significant interaction of FMD and PEP recovery for IMT (p = 0.006). Among participants with low FMD, slower PEP recovery was related to higher IMT. Among individuals with high FMD, slow RSA recovery predicted higher IMT. No significant interactions of FMD and cardiac reactivity for IMT were found. Conclusions Cardiac recovery plays a role in atherosclerosis development in persons with high and low FMD. The role of sympathetically mediated cardiac activity seems to be more important in those with impaired FMD, and parasympathetically mediated in those with relatively high FMD. The development of endothelial dysfunction may be one possible mechanism linking slow cardiac recovery and atherosclerosis via autonomic nervous system mediated effect.