Carotid artery elasticity decreases during pregnancy - the Cardiovascular Risk in Young Finns study

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• 作者：Henna K?rkk?inen (18)
  Heli Saarelainen (18)
  Pirjo Valtonen (19)
  Tiina Laitinen (20)
  Olli T Raitakari (21) (22)
  Markus Juonala (21) (23)
  Mika K?h?nen (24)
  Nina Hutri-K?h?nen (25)
  Seppo Heinonen (18)
  Tomi Laitinen (20)
  
• 关键词：Carotid artery ; Elasticity ; Pregnancy ; Distensibility ; Arterial stiffness ; The Cardiovascular Risk in Young Finns study
• 刊名：BMC Pregnancy and Childbirth
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：206 KB
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  27. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2393/14/98/prepub
  
• 作者单位：Henna K?rkk?inen (18)
  Heli Saarelainen (18)
  Pirjo Valtonen (19)
  Tiina Laitinen (20)
  Olli T Raitakari (21) (22)
  Markus Juonala (21) (23)
  Mika K?h?nen (24)
  Nina Hutri-K?h?nen (25)
  Seppo Heinonen (18)
  Tomi Laitinen (20)
  
  18. Department of Obst/Gyn, Kuopio University Hospital, University of Eastern Finland, P.O.B. 100FIN, 70029, Kuopio, Finland
  19. Eastern Finland Laboratory Centre Joint Authority Enterprise (ISLAB), Mikkeli Regional Laboratory, Mikkeli, Finland
  20. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
  21. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
  22. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
  23. Department of Internal Medicine, Turku University Hospital, Turku, Finland
  24. Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
  25. Department of Pediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland
  
• ISSN：1471-2393

文摘

Background The aims were to evaluate the effect of pregnancy on carotid artery elasticity and determine the associations between maternal lipids, endothelial function and arterial elasticity during pregnancy. Methods We examined 99 pregnant and 99 matched non-pregnant control women as part of a population-based prospective cohort study. Carotid artery elasticity indexes; carotid artery distensibility (CAD), Young’s elastic modulus (YEM) and stiffness index (SI) as well as brachial artery flow-mediated dilation (FMD) were assessed using ultrasound; serum lipid levels were also determined. Results SI was 57% and YEM 75% higher and CAD 36% lower in the third trimester group than the corresponding values in the first trimester group. Serum cholesterol and triglyceride levels were significantly higher in women at the end of the pregnancy than at the beginning of pregnancy (P-lt;-.001) and in controls (P-lt;-.001). In multivariate analysis, gestational age was the only independent correlate of arterial elasticity in pregnant women. In controls, age (P?≤-.001) and common carotid diameter (P--.001-0.029) were associated with SI, YEM and CAD. Conclusions The present study revealed that carotid artery elasticity declined towards the end of the pregnancy; this neither is straight correlating with maternal hyperlipidemia or the diameter of the carotid artery nor is it associated with changes in endothelial function.