The Development of Gastric Cancer in a Patient with Polycythemia Vera, 3P Deletion, and JAK2 V617F Mutation

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• 作者：Ozlem Ayvaz (1)
  Irfan Yavasoglu (1)
  Gurhan Kadikoylu (1)
  Nezih Meydan (2)
  Sabri Barutca (2)
  Zahit Bolaman (1)
  
• 关键词：3p deletion ; JAKV617F ; polycythemia vera ; gastric cancer
• 刊名：Journal of Gastrointestinal Cancer
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：41
• 期：4
• 页码：254-256
• 全文大小：92KB
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• 作者单位：Ozlem Ayvaz (1)
  Irfan Yavasoglu (1)
  Gurhan Kadikoylu (1)
  Nezih Meydan (2)
  Sabri Barutca (2)
  Zahit Bolaman (1)
  
  1. Division of Hematology, Adnan Menderes University Medical Faculty, 09100, Aydin, Turkey
  2. Division of Oncology, Adnan Menderes University Medical Faculty, Aydin, Turkey
  
• ISSN：1941-6636

文摘

3p deletion which is frequently associated with solitary tumors and hematological malignancies is a chromosomal abnormality. Recently, Janus kinase-2 (JAK2) V617F mutation has an important role in the diagnosis of myeloproliferative disorders, especially in polycythemia vera (PV). We reported the development of gastric cancer in a 75-year-old patient with PV, 3p 12-14 deletion and JAK2 V617F mutation. PV was diagnosed according to the classification of World Health Organization. JAK2 V617F mutation with polymerase chain reaction and 3p12-14 deletion with cytogenetic examination of the bone marrow were detected. We investigated solitary tumors in the patient using computed tomographies of thorax, neck, ear, nose, and throat. However, they were normal. After 2 years, gastric cancer appeared in the patient. In conclusion, cytogenetic examination may be important in both the development and the diagnosis of hematological malignancies and solitary tumors. So the patients should be followed closely.