Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A_lus-plus">2 (Lp-PLA_lus-plus">2) Inhibitor [^lus-plus">18F]GSK2647544 in Healthy Male Subjects

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• 作者：Mickael Huiban ; Christopher Coello ; Kai Wu ; Yanmei Xu…
• 关键词：Key wordsLp ; PLA2 ; PET ; Alzheimer’s disease ; GSK2647544 ; Biodistribution ; Positron emission tomography
• 刊名：Molecular Imaging and Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：1
• 页码：153-161
• 全文大小：2060KB
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002
• 卷排序：19

文摘

PurposeGSK2647544 is a potent and specific inhibitor of lipoprotein-associated phospholipase A₂ (Lp-PLA₂), which was in development as a potential treatment for Alzheimer’s disease (AD). In order to refine therapeutic dose predictions and confirm brain penetration, a radiolabelled form of the inhibitor, [18F]GSK2647544, was manufactured for use in a positron emission tomography (PET) biodistribution study.