Biological effects of obestatin

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• 作者：Jiang-Bo Li (1)
  Akihiro Asakawa (1)
  KaiChun Cheng (1)
  Yingxiao Li (1)
  Huhe Chaolu (1)
  Minglun Tsai (1)
  Akio Inui (1)
  
• 关键词：Obestatin ; GPR39 ; Acylated ghrelin ; Des ; acyl ghrelin ; Biological effects
• 刊名：Endocrine
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：39
• 期：3
• 页码：205-211
• 全文大小：271KB
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• 作者单位：Jiang-Bo Li (1)
  Akihiro Asakawa (1)
  KaiChun Cheng (1)
  Yingxiao Li (1)
  Huhe Chaolu (1)
  Minglun Tsai (1)
  Akio Inui (1)
  
  1. Division of Psychosomatic Internal Medicine, Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan
  

文摘

Obestatin, a 23-amino-acid peptide, is derived from the preproghrelin precursor. Obestatin was identified in 2005 as a hormone regulating food intake and energy, and having opposite effects to those of ghrelin. However, as studies have progressed, many disputes on the physiological function of obestatin have emerged. The food intake suppressive effects of obestatin have not been replicated in many studies. Nonetheless, many biological roles of obestatin have been revealed, and obestatin is thought to be associated with a variety of biological functions such as feeding, drinking, incretion, memory, and sleep, and with neuropsychiatric manifestations. The biological effects of obestatin will be reviewed in this article.