Expression and clinical significance of CRABP1 and CRABP2 in non-small cell lung cancer
详细信息 查看全文
- 作者：Irina Favorskaya (1)
Yaroslav Kainov (1)
Galina Chemeris (2)
Andrei Komelkov (1)
Irina Zborovskaya (1)
Elena Tchevkina (1) - 关键词：Non ; small cell lung cancer ; NSCLC ; CRABP1 ; CRABP2 ; Retinoic acid
- 刊名：Tumor Biology
- 出版年：2014
- 出版时间：October 2014
- 年：2014
- 卷：35
- 期：10
- 页码：10295-10300
- 全文大小：500 KB
- 参考文献：1. Bushue N, Wan YJ. Retinoid pathway and cancer therapeutics. Adv Drug Deliv Rev. 2010;62(13):1285-8. doi:10.1016/j.addr.2010.07.003 . CrossRef
2. Theodosiou M, Laudet V, Schubert M. From carrot to clinic: an overview of the retinoic acid signaling pathway. Cell Mol Life Sci CMLS. 2010;67(9):1423-5. doi:10.1007/s00018-010-0268-z . CrossRef
3. Dong D, Ruuska SE, Levinthal DJ, Noy N. Distinct roles for cellular retinoic acid-binding proteins I and II in regulating signaling by retinoic acid. J Biol Chem. 1999;274(34):23695-. CrossRef
4. Budhu AS, Noy N. Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. Mol Cell Biol. 2002;22(8):2632-1. CrossRef
5. Ross AC. Cellular metabolism and activation of retinoids: roles of cellular retinoid-binding proteins. FASEB J Off Publ Fed Am Soc Exp Biol. 1993;7(2):317-7.
6. Won JY, Nam EC, Yoo SJ, Kwon HJ, Um SJ, Han HS, et al. The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma. Metab Clin Exp. 2004;53(8):1007-2. CrossRef
7. Napoli JL. Interactions of retinoid binding proteins and enzymes in retinoid metabolism. Biochim Biophys Acta. 1999;1440(2-):139-2. CrossRef
8. Fiorella PD, Napoli JL. Expression of cellular retinoic acid binding protein (CRABP) in Escherichia coli. Characterization and evidence that holo-CRABP is a substrate in retinoic acid metabolism. J Biol Chem. 1991;266(25):16572-.
9. Tang XH, Vivero M, Gudas LJ. Overexpression of CRABPI in suprabasal keratinocytes enhances the proliferation of epidermal basal keratinocytes in mouse skin topically treated with all-trans retinoic acid. Exp Cell Res. 2008;314(1):38-1. doi:10.1016/j.yexcr.2007.07.016 . CrossRef
10. Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, et al. Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma. Oncogene. 2007;26(44):6456-8. doi:10.1038/sj.onc.1210459 . CrossRef
11. Lee HS, Kim BH, Cho NY, Yoo EJ, Choi M, Shin SH, et al. Prognostic implications of and relationship between CpG island hypermethylation and repetitive DNA hypomethylation in hepatocellular carcinoma. Clin Cancer Res Off J Am Assoc Cancer Res. 2009;15(3):812-0. doi:10.1158/1078-0432.CCR-08-0266 . CrossRef
12. Calmon MF, Rodrigues RV, Kaneto CM, Moura RP, Silva SD, Mota LD, et al. Epigenetic silencing of CRABP2 and MX1 in head and neck tumors. Neoplasia. 2009;11(12):1329-9.
13. Geiger T, Madden SF, Gallagher WM, Cox J, Mann M. Proteomic portrait of human breast cancer progression identifies novel prognostic markers. Cancer Res. 2012;72(9):2428-9. doi:10.1158/0008-5472.CAN-11-3711 . CrossRef
14. Ramakers C, Ruijter JM, Deprez RH, Moorman AF. Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci Lett. 2003;339(1):62-. CrossRef
15. Osanai M, Sawada N, Lee GH. Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1. Oncogene. 2010;29(8):1135-4. doi:10.1038/onc.2009.414 . Kainov (1)
Galina Chemeris (2)
Andrei Komelkov (1)
Irina Zborovskaya (1)
Elena Tchevkina (1)
1. Oncogenes Regulation Department, Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Kashirskoye shosse 24, Moscow, Russia, 115478
2. Human Tumor Pathology Department, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Kashirskoye shosse 23, Moscow, Russia, 115478 - ISSN：1423-0380
文摘
The impairment of retinoic acid (RA)-dependent signaling is a frequent event during carcinogenesis. Cellular retinoic acid-binding proteins (CRABP1 and CRABP2) are important modulators of RA activity. Up to date, the role of these proteins in cancer progression remains poorly investigated. Here, we studied for the first time the simultaneous messenger RNA (mRNA) and protein expression of CRABPs in non-small cell lung cancer (NSCLC) samples. CRABP1 and CRABP2 mRNA levels were elevated in 42 and 56?% of NSCLC samples, respectively. Decrease of CRABP2 mRNA expression was significantly associated with the presence of lymph node metastases. Protein expression of CRABP1 and CRABP2 was detected in 50 and 56?% of tumor samples, respectively. We also found a positive correlation between CRABP1 and CRABP2 expression. Taken together, we demonstrated significant changes in CRABP expression in NSCLC samples. Importantly, the presented data provide the first evidence of potential involvement of CRABP2 in lung cancer metastasis.