Effect of troglitazone on the excess testosterone and LH secretion in thyroidectomized, insulin-resistant, type 2 diabetic Goto-kakizaki rats

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• 作者：Mayumi Matsushita (1)
  Kazuhiro Tamura (1)
  Shingo Osada (1)
  Hiroshi Kogo (1)
  
• 关键词：Troglitazone ; testosterone ; luteinizing hormone receptor ; hypothyroidism ; insulin resistance ; Goto ; Kakizaki (GK) rat
• 刊名：Endocrine
• 出版年：2005
• 出版时间：August 2005
• 年：2005
• 卷：27
• 期：3
• 页码：301-305
• 全文大小：181KB
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• 作者单位：Mayumi Matsushita (1)
  Kazuhiro Tamura (1)
  Shingo Osada (1)
  Hiroshi Kogo (1)
  
  1. Department of Endocrine Pharmacology, Tokyo, University of Pharmacy and Life Science, 1432-1, Horinouchi, 192-0392, Hachioji-shi, Japan
  

文摘

Our previous study suggested that hypothyroidism in Goto-Kakizaki (GK) rats with insulin resistance and type 2 diabtetes elevates their serum testosterone and luteinizing hormone (LH) levels and ovarian LH receptor messenger RNA (mRNA) expression. The present study assessed the effects of troglitazone (Tro), an insulin-sensitizing agent, on these hypothyroidism-induced hormonal changes in GK rats. GK and normal (Wistar strain) female rats were thyroidectomized (Tx) and then injected with 5 IU of equine chorionic gonadotropin (eCG) for 5 d starting 1 wk after thyroidectomy (the control groups). In the test groups, Tx GK and Wistar rats were injected with both eCG and Tro (100 mg kg?) po for 5 d. Tro treatment had no effect on the elevated LH serum levels in eCG-treated Tx GK rats but suppressed their enhanced serum testosterone levels as well as significantly decreasing their LH receptor mRNA expression. Tro lowered testosterone and LH receptor mRNA levels in cultured theca cells. These results indicate that Tro lowers the elevated testosterone secretion and ovarian LH receptor mRNA expression that is induced in GK rats by Tx and gonadotropin treatment, which suggests that insulin resistance may be involved in enhancing testosterone production and LH receptor expression in the ovary.