Wall motion in the stenotic carotid artery: association with greyscale plaque characteristics, the degree of stenosis and cerebrovascular symptoms

详细信息    查看全文

• 作者：Baris Kanber (1)
  Timothy C Hartshorne (1) (2)
  Mark A Horsfield (1)
  Andrew R Naylor (1) (2)
  Thompson G Robinson (1) (3)
  Kumar V Ramnarine (4)
  
• 关键词：Ultrasound ; Carotid artery ; Carotid plaque ; Stenosis ; Wall motion ; Distension ; Dilation ; Greyscale median ; GSM ; Surface irregularity index ; SII ; Cerebrovascular symptoms
• 刊名：Cardiovascular Ultrasound
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：11
• 期：1
• 全文大小：650 KB
• 参考文献：1. Hellings WE, Peeters W, Moll FL, Piers SRD, Van Setten J, Van Spek D, Peter J, De Vries JPM, Seldenrijk KA, De Bruin PC, Vink A, Velema E, De Kleijn DPV, Pasterkamp G: Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study. / Circulation 2010,121(17):1941-950. CrossRef
  2. Elatrozy T, Nicolaides A, Tegos T, Griffin M: The objective characterisation of ultrasonic carotid plaque features. / Eur J Vasc Endovasc Surg 1998,16(3):223-30. CrossRef
  3. Tegos TJ, Stavropoulos P, Sabetai MM, Khodabakhsh P, Sassano A, Nicolaides AN: Determinants of carotid plaque instability: echoicity versus heterogeneity. / Eur J Vasc Endovasc Surg 2001,22(1):22-0. CrossRef
  4. Biasi GM, Sampaolo A, Mingazzini P, De Amicis P, El-barghouty N, Nicolaides AN: Computer analysis of ultrasonic plaque echolucency in identifying high risk carotid bifurcation lesions. / Eur J Vasc Endovasc Surg 1999,17(6):476-79. CrossRef
  5. Salem MK, Sayers RD, Bown MJ, West K, Moore D, Nicolaides A, Robinson TG, Naylor AR: Patients with recurrent ischaemic events from carotid artery disease have a large lipid core and low GSM. / Eur J Vasc Endovasc Surg 2012,43(2):147-53. CrossRef
  6. Gr?nholdt ML, Nordestgaard BG, Schroeder TV, Vorstrup S, Sillesen H: Ultrasonic echolucent carotid plaques predict future strokes. / Circulation 2001,104(1):68-3. CrossRef
  7. Polak JF, Shemanski L, Leary DH, Lefkowitz D, Price TR, Savage PJ, Brant WE, Reid C: Hypoechoic plaque at US of the carotid artery: an independent risk factor for incident stroke in adults aged 65 years or older. Cardiovascular Health Study. / Radiology 1998,208(3):649-54.
  8. Kanber B, Hartshorne TC, Horsfield MA, Naylor AR, Robinson TG, Ramnarine KV: Dynamic variations in the ultrasound greyscale median of carotid artery plaques. / Cardiovasc Ultrasound 2013,11(1):21. CrossRef
  9. Prabhakaran S, Rundek T, Ramas R, Elkind MSV, Paik MC, Boden-albala B, Sacco RL: Carotid plaque surface irregularity predicts ischemic stroke: the northern Manhattan study. / Stroke 2006,37(11):2696-701. CrossRef
  10. Kanber B, Hartshorne TC, Horsfield MA, Naylor AR, Robinson TG, Ramnarine KV: Quantitative Assessment of Carotid Plaque Surface Irregularities and Correlation to Cerebrovascular Symptoms. / Cardiovasc Ultrasound in press
  11. Ramnarine KV, Garrard JW, Dexter K, Nduwayo S, Panerai RB, Robinson TG: Shear wave elastography assessment of carotid plaque stiffness: in-vitro reproducibility study. / Ultrasound Med Biol 2013. in press
  12. Dijk JM, Van Der Graaf Y, Grobbee DE, Banga JD, Bots ML: Increased arterial stiffness is independently related to cerebrovascular disease and aneurysms of the abdominal aorta: the second manifestations of arterial disease (SMART) study. / Stroke 2004,35(7):1642-646. CrossRef
  13. Leone N, Ducimetière P, Gariépy J, Courbon D, Tzourio C, Dartigues J, Ritchie K, Alpérovitch A, Amouyel P, Safar ME, Zureik M: Distension of the carotid artery and risk of coronary events: the three-city study. / Arterioscler Thromb Vasc Biol 2008,28(7):1392-397. CrossRef
  14. Agabiti-rosei E, Muiesan ML: Carotid atherosclerosis, arterial stiffness and stroke events. / Adv Cardiol 2006, 44:173-86. CrossRef
  15. Rothwell PM: Carotid artery disease and the risk of ischaemic stroke and coronary vascular events. / Cerebrovasc Dis 2000,10(Suppl 5):21-3. CrossRef
  16. Lenzi GL, Vicenzini E: The ruler is dead: an analysis of carotid plaque motion. / Cerebrovasc Dis 2006,23(2-):121-25.
  17. Kashiwazaki D, Yoshimoto T, Mikami T, Muraki M, Fujimoto S, Abiko K, Kaneko S: Identification of high-risk carotid artery stenosis: motion of intraplaque contents detected using B-mode ultrasonography. / J Neurosurg 2013,117(3):574-78. CrossRef
  18. Kume S, Hama S, Yamane K, Wada S, Nishida T, Kurisu K: Vulnerable carotid arterial plaque causing repeated ischemic stroke can be detected with B-mode ultrasonography as a mobile component: jellyfish sign. / Neurosurg Rev 2011,33(4):419-30. CrossRef
  19. Meairs S, Hennerici M: Four-dimensional ultrasonographic characterization of plaque surface motion in patients with symptomatic and asymptomatic carotid artery stenosis. / Stroke 1999,30(9):1807-813. CrossRef
  20. Bang J, Dahl T, Bruinsma A, Kaspersen JH, Nagelhus Hernes TA, Myhre HO: A new method for analysis of motion of carotid plaques from RF ultrasound images. / Ultrasound Med Biol 2003,29(7):967-76. CrossRef
  21. Giannattasio C, Failla M, Emanuelli G, Grappiolo A, Boffi L, Corsi D, Mancia G: Local effects of atherosclerotic plaque on arterial distensibility. / Hypertension 2001,38(5):1177-180. CrossRef
  22. Lee KW, Wood NB, Xu XY: Ultrasound image-based computer model of a common carotid artery with a plaque. / Med Eng Phys 2004,26(10):823-40. CrossRef
  23. Hsu H, Chen Y, Sheu WH, Sheng W, Chao A: Comparison of brachial artery flow-mediated vasodilatation in symptomatic and asymptomatic patients with carotid arterial stenosis. / Am J Cardiol 2002,90(7):814-16. CrossRef
  24. Ramnarine KV, Hartshorne T, Sensier Y, Naylor M, Walker J, Naylor AR, Panerai RB, Evans DH: Tissue Doppler imaging of carotid plaque wall motion: a pilot study. / Cardiovasc Ultrasound 2003, 1:17. CrossRef
  25. Paini A, Boutouyrie P, Calvet D, Zidi M, Agabiti-rosei E, Laurent S: Multiaxial mechanical characteristics of carotid plaque: analysis by multiarray echotracking system. / Stroke 2006,38(1):117-23. CrossRef
  26. Beaussier H, Naggara O, Calvet D, Joannides R, Guegan-massardier E, Gerardin E, Iacob M, Laloux B, Bozec E, Bellien J, Touze E, Masson I, Thuillez C, Oppenheim C, Boutouyrie P, Laurent S: Mechanical and structural characteristics of carotid plaques by combined analysis with echotracking system and MR imaging. / JACC Cardiovasc Imaging 2011,4(5):468-77. CrossRef
  27. Jansen M, Van Alfen N, Nijhuis Van Der Sanden MWG, Van Dijk JP, Pillen S, De Groot IJM: Quantitative muscle ultrasound is a promising longitudinal follow-up tool in Duchenne muscular dystrophy. / Neuromuscul Disord 2012,22(4):306-17. CrossRef
  28. Kanber B, Ramnarine KV: / A Probabilistic Approach to Computerized Tracking of Arterial Walls in Ultrasound Image Sequences. ISRN Signal Processing. 2012.
  29. Ramnarine KV, Kanber B, Panerai RB: Assessing the performance of vessel wall tracking algorithms: the importance of the test phantom. / J Phys Conf Ser 2004, 1:199-04. CrossRef
  30. North American Symptomatic Carotid Endarterectomy Trial Collaborators: Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. / N Engl J Med 1991,325(7):445-53. CrossRef
  31. Grant EG, Benson CB, Moneta GL, Alexandrov AV, Baker JD, Bluth EI, Carroll BA, Eliasziw M, Gocke J, Hertzberg BS, Katanick S, Needleman L, Pellerito J, Polak JF, Rholl KS, Wooster DL, Zierler RE: Carotid artery stenosis: gray-scale and Doppler US diagnosis–society of radiologists in ultrasound consensus conference. / Radiology 2003,229(2):340-46. CrossRef
  32. Oates CP, Naylor AR, Hartshorne T, Charles SM, Fail T, Humphries K, Aslam M, Khodabakhsh P: Joint recommendations for reporting carotid ultrasound investigations in the United Kingdom. / Eur J Vasc Endovasc Surg 2008,37(3):251-61. CrossRef
  33. Long Q, Xu XY, Ramnarine KV, Hoskins P: Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis. / J Biomech 2001,34(10):1229-242. CrossRef
  34. Meagher S, Poepping TL, Ramnarine KV, Black RA, Hoskins PR: Anatomical flow phantoms of the nonplanar carotid bifurcation, part II: experimental validation with Doppler ultrasound. / Ultrasound Med Biol 2007,33(2):303-10. CrossRef
  35. Watts DM, Sutcliffe CJ, Morgan RH, Meagher S, Wardlaw J, Connell M, Bastin ME, Marshall I, Ramnarine KV, Hoskins PR, Black RA: Anatomical flow phantoms of the nonplanar carotid bifurcation, part I: computer-aided design and fabrication. / Ultrasound Med Biol 2007,33(2):296-02. CrossRef
  36. Schmidt-trucks?ss A, Grathwohl D, Schmid A, Boragk R, Upmeier C, Keul J, Huonker M: Structural, functional, and hemodynamic changes of the common carotid artery with age in male subjects. / Arterioscler Thromb Vasc Biol 1999,19(4):1091-097. CrossRef
  37. Kanters SD, Elgersma OE, Banga JD, Van Leeuwen MS, Algra A: Reproducibility of measurements of intima-media thickness and distensibility in the common carotid artery. / Eur J Vasc Endovasc Surg 1998,16(1):28-5. CrossRef
  38. Godia EC, Madhok R, Pittman J, Trocio S, Ramas R, Cabral D, Sacco RL, Rundek T: Carotid artery distensibility: a reliability study. / J Ultrasound Med 2007,26(9):1157-165.
  
• 作者单位：Baris Kanber (1)
  Timothy C Hartshorne (1) (2)
  Mark A Horsfield (1)
  Andrew R Naylor (1) (2)
  Thompson G Robinson (1) (3)
  Kumar V Ramnarine (4)
  
  1. Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
  2. Department of Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK
  3. NIHR Biomedical Research Unit for Cardiovascular Sciences, University of Leicester, Leicester, UK
  4. Department of Medical Physics, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW, UK
  
• ISSN：1476-7120

文摘

Background Systolic dilation of the atherosclerotic carotid artery depends on several factors including arterial compliance and the haemodynamic environment. The purpose of this study was to quantify wall motion in stenotic carotid arteries and investigate any associations with the ultrasound greyscale plaque characteristics, the degree of stenosis, and the presence of cerebrovascular symptoms. Methods Variations in the lumen diameters of 61 stenotic carotid arteries (stenosis range 10%-95%) from 47 patients were measured before the proximal shoulder of the atherosclerotic plaque using ultrasound image sequences over several cardiac cycles. Absolute and percentage diameter changes from diastole to systole were calculated and their relationship to the degree of stenosis, greyscale plaque characteristics, and the presence of ipsilateral hemispheric symptoms were studied. Results The mean absolute diameter change from diastole to systole was 0.45?mm (s.d. 0.17), and the mean percentage diameter change was 6.9% (s.d. 3.1%). Absolute and percentage diameter changes did not have a statistically significant relationship to the degree of stenosis, greyscale plaque characteristics, or the presence of ipsilateral hemispheric symptoms (p-gt;-.05). Parameters significantly correlated with the presence of symptoms were the degree of stenosis (p--.01), plaque greyscale median (p--.02) and the plaque surface irregularity index (p--.02). Conclusions Our study confirmed the degree of stenosis, plaque greyscale median and our surface irregularity index were significant predictors of symptoms, but found no significant correlation between diameter changes of stenosed carotid arteries and the presence of ipsilateral hemispheric symptoms.