Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
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- 作者：Michael Lattke ; Stephanie N. Reichel ; Alexander Magnutzki…
- 关键词：NF ; kappaB ; IKK ; Neuroinflammation ; Cerebellar ataxia ; Purkinje cell degeneration ; Bergmann glia ; Glutamate transporter ; EAAT ; Excitotoxicity
- 刊名：Molecular Neurodegeneration
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：12
- 期：1
- 全文大小：12795KB
- 刊物主题：Neurosciences; Neurology; Molecular Medicine;
- 出版者：BioMed Central
- ISSN：1750-1326
- 卷排序：12
文摘
BackgroundNeuroinflammation is associated with a wide range of neurodegenerative disorders, however the specific contribution to individual disease pathogenesis and selective neuronal cell death is not well understood. Inflammatory cerebellar ataxias are neurodegenerative diseases occurring in various autoimmune/inflammatory conditions, e.g. paraneoplastic syndromes. However, how inflammatory insults can cause selective cerebellar neurodegeneration in the context of these diseases remains open, and appropriate animal models are lacking. A key regulator of neuroinflammatory processes is the NF-κB signalling pathway, which is activated by the IκB kinase 2 (IKK2) in response to various pathological conditions. Importantly, its activation is sufficient to initiate neuroinflammation on its own.