Effect of early life stress on pancreatic isolated islets-insulin secretion in young adult male rats subjected to chronic stress

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• 作者：Forouzan Sadeghimahalli ; Roxana Karbaschi ; Homeira Zardooz ; Fariba Khodagholi…
• 关键词：Early life stress ; Young adulthood stress ; GLUT2 level ; HOMA ; IR index ; Corticosterone ; Insulin secretion ; Glucose tolerance ; Adrenal glands weight
• 刊名：Endocrine
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：48
• 期：2
• 页码：493-503
• 全文大小：402 KB
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• 刊物主题：Endocrinology; Diabetes; Internal Medicine; Science, general;
• 出版者：Springer US
• ISSN：1559-0100

文摘

Early stressful experiences may predispose organisms to certain disorders, including those of metabolic defects. This study aimed to explore the effects of early life stress on pancreatic insulin secretion and glucose transporter 2 (GLUT2) protein levels in stressed young adult male rats. Foot shock stress was induced in early life (at 2?weeks of age) and/or in young adulthood (at 8-0?weeks of age) for five consecutive days. Blood samples were taken before and after stress exposure in young adult rats. At the end of the experiment, glucose tolerance, isolated islets-insulin secretion, and pancreatic amounts of GLUT2 protein were measured. Our results show that early life stress has no effect on basal plasma corticosterone levels and adrenal weight, either alone or combined with young adulthood stress, but that early life?+?young adulthood stress could prevent weight gain, and cause an increase in basal plasma glucose and insulin. The homeostasis model assessment of insulin resistance index did not increase, when the rats were subjected to early life stress alone, but increased when combined with young adulthood stress. Moreover, glucose tolerance was impaired by the combination of early life?+?young adult stress. There was a decrease in islet’s insulin secretion in rats subjected to early life stress in response to 5.6?mM glucose concentration, but an increase with a concentration of 16.7?mM glucose. However, in rats subjected to early life?+?young adulthood stress, islet’s insulin secretion increased in response to both the levels of glucose concentrations. GLUT2 protein levels decreased in response to early life stress and early life?+?young adulthood stress, but there was a greater decrease in the early life stress group. In conclusion, perhaps early life stress sensitizes the body to stressors later in life, making it more susceptible to metabolic syndrome only when the two are in combination.