Fibronectin Mechanobiology Regulates Tumorigenesis

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• 作者：Karin Wang ; Bo Ri Seo ; Claudia Fischbach…
• 关键词：Fibronectin conformational flexibility ; Fibronectin mechanics ; Tumor stroma ; Tumor progression
• 刊名：Cellular and Molecular Bioengineering
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：9
• 期：1
• 页码：1-11
• 全文大小：913 KB
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• 作者单位：Karin Wang (1) (2)
  Bo Ri Seo (2)
  Claudia Fischbach (2) (3)
  Delphine Gourdon (1) (2)
  
  1. Department of Materials Science and Engineering, Cornell University, 327 Bard Hall, Ithaca, NY, 14853, USA
  2. Department of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA
  3. Kavli Institute at Cornell for Nanoscale Science, Cornell University, Ithaca, NY, 14853, USA
  
• 刊物类别：Engineering
• 刊物主题：Biomedical Engineering
  Mechanics
  Continuum Mechanics and Mechanics of Materials
  Biophysics and Biomedical Physics
  Cell Biology
  
• 出版者：Springer New York
• ISSN：1865-5033

文摘

Fibronectin (Fn) is an essential extracellular matrix (ECM) glycoprotein involved in both physiological and pathological processes. The structure–function relationship of Fn has been and is still being studied, as changes in its molecular structure are integral in regulating (or dysregulating) its biological activities via its cell, matrix component, and growth factor binding sites. Fn comprises three types of repeating modules; among them, FnIII modules are mechanically unstable domains that may be extended/unfolded upon cell traction and either uncover cryptic binding sites or disrupt otherwise exposed binding sites. Cells assemble Fn into a fibrillar network; its conformational flexibility implicates Fn as a critical mechanoregulator of the ECM. Fn has been shown to contribute to altered stroma remodeling during tumorigenesis. This review will discuss (i) the significance of the structure–function relationship of Fn at both the molecular and the matrix scales, (ii) the role of Fn mechanobiology in the regulation of tumorigenesis, and (iii) Fn-related advances in cancer therapy development. Keywords Fibronectin conformational flexibility Fibronectin mechanics Tumor stroma Tumor progression