Vitamin B12, Folic Acid, and Bone

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• 作者：Karin M. A. Swart (1)
  Natasja M. van Schoor (1)
  Paul Lips (2)
  
• 关键词：Vitamin B12 ; Folate ; Homocysteine ; MTHFR ; Fracture ; Bone ; Physical function ; Falls
• 刊名：Current Osteoporosis Reports
• 出版年：2013
• 出版时间：September 2013
• 年：2013
• 卷：11
• 期：3
• 页码：213-218
• 全文大小：
• 作者单位：Karin M. A. Swart (1)
  Natasja M. van Schoor (1)
  Paul Lips (2)
  
  1. Department of Epidemiology and Biostatistics and the EMGO Institute of Health and Care Research, VU University Medical Center, Van de Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
  2. Department of Internal Medicine/Endocrinology and the EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands
  
• ISSN：1544-2241

文摘

Vitamin B12 and folic acid deficiency are associated with a higher serum concentration of homocysteine. A high serum homocysteine is a risk factor for fractures. Both vitamins play a role in the remethylation of homocysteine to methionine. The pathophysiology from a high serum homocysteine to fractures is not completely clear, but might involve bone mineral density, bone turnover, bone blood flow, DNA methylation, and/or physical function and fall risk. Genetic variation, especially polymorphisms of the gene encoding for methylenetetrahydrofolate reductase may play a role in homocysteine metabolism and fracture risk. It is uncertain whether supplementation with vitamin B12 and folate can decrease fracture incidence. One double blind clinical trial in post-stroke patients showed that these B vitamins could decrease hip fracture incidence, but the results of further clinical trials should be awaited before a definite conclusion can be drawn.