TGFB1 gene polymorphism Leu10Pro (c.29T>C), prostate cancer incidence and quality of life in patients treated with brachytherapy
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- 作者：Andreas Meyer ; Thilo D?rk ; Natalia Bogdanova ; Maria-Jantje Brinkhaus ; Birgitt Wiese ; J?rn Hagemann ; J¨¹rgen Serth ; Michael Bremer ; Rolf Baumann and Johann H. Karstens ; et al.
- 关键词：Brachytherapy ; Late effects ; Prostate cancer ; TGFB1 gene polymorphism
- 刊名：World Journal of Urology
- 出版年：2009
- 出版时间：June, 2009
- 年：2009
- 卷：27
- 期：3
- 页码：371-377
- 全文大小：309.3 KB
文摘
Objectives Transforming growth factor beta1 gene (TGFB1) variant Leu10Pro (L10P) has previously been implicated in prostate cancer risk and radiation-induced side-effects. We investigated whether prevalence of this polymorphism is increased in prostate cancer patients and whether carriers are at increased risk for treatment-related side effects.