B-lymphoblastic transformation of mantle cell lymphoma/leukemia with “double hit-changes

详细信息    查看全文

• 作者：Michael E. Kallen ; Nagesh P. Rao ; Sameer K. Kulkarni…
• 关键词：B ; lymphoblastic leukemia ; Mantle cell lymphoma ; Double hit lymphoma ; Blastic TdT ; positive leukemia
• 刊名：Journal of Hematopathology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：8
• 期：1
• 页码：31-36
• 全文大小：6,985 KB
• 参考文献：1. Swerdlow, SH, Campo, E, Harris, NL (2008) WHO classification of tumours of haematopoietic and lymphoid tissues. IARC, Lyon
  2. Hsi, ED, Martin, P (2014) Indolent mantle cell lymphoma. Leuk Lymphoma 55: pp. 761-767 CrossRef
  3. Holdener, SL, Harrington, L, Nguyen, J, Horna, P, Sagatys, E, Shah, B, Zhang, L (2014) Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy—a unique case report. Int J Clin Exp Pathol 7: pp. 1800-1804
  4. Felten, CL, Stephenson, CF, Ortiz, RO, Hertzberg, L (2004) Burkitt transformation of mantle cell lymphoma. Leuk Lymphoma 45: pp. 2143-2147 CrossRef
  5. Tamaru, JI, Kawana, H, Takahashi, Y, Takahashi, N, Isobe, K, Hirai, A, Saito, Y, Harigaya, K, Itoyama, S, Mikata, A (1999) Expression of cell cycle regulating proteins in an unusual transformation of mantle cell lymphoma. Leuk Lymphoma 36: pp. 128-137
  6. Pérez-Galán, P, Dreyling, M, Wiestner, A (2011) Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era. Blood 117: pp. 26-38 CrossRef
  7. Jares, P, Colomer, D, Campo, E (2007) Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. Nat Rev Cancer 7: pp. 750-762 CrossRef
  8. Setoodeh, R, Schwartz, S, Papenhausen, P (2013) Double-hit mantle cell lymphoma with MYC gene rearrangement or amplification: a report of four cases and review of the literature. Int J Clin Exp Pathol 6: pp. 155-167
  9. ISCN (2013) International System of Human Cytogenetic Nomenclature, Shaffer LG, McGowan-Jordan J, Schmid M (eds); S. Karger, Basel 2013
  10. Rodriguez-Justo, M, Huang, Y, Ye, H, Liu, H, Chuang, SS, Munson, P, Prada-Puentes, C, Kim, I, Du, MQ, Bacon, CM (2008) Cyclin D1-positive diffuse large B-cell lymphoma. Histopathology 52: pp. 900-903 CrossRef
  11. Zanetto, U, Dong, H, Huang, Y, Zhang, K, Narbaitz, M, Sapia, S, Kostopoulos, I, Liu, H, Du, MQ, Bacon, CM (2008) Mantle cell lymphoma with aberrant expression of CD10. Histopathology 53: pp. 20-29 CrossRef
  12. Sriganeshan, V, Blom, TR, Weissmann, DJ (2008) A unique case of mantle cell lymphoma with an aberrant CD5?CD10+ immunophenotype and typical morphology. Arch Pathol Lab Med 132: pp. 1346-1349
  13. Morice, WG, Hodnefield, JM, Kurtin, PJ, Hanson, CA (2004) An unusual case of leukemic mantle cell lymphoma with a blastoid component showing loss of CD5 and aberrant expression of CD10. Am J Clin Pathol 122: pp. 122-127 CrossRef
  14. Nelson, BP, Treaba, D, Goolsby, C, Williams, S, Dewald, G, Gordon, L, Peterson, LC (2006) Surface immunoglobulin positive lymphoblastic leukemia in adults; a genetic spectrum. Leuk Lymphoma 47: pp. 1352-1359 CrossRef
  15. Hirzel, AC, Cotrell, A, Gasparini, R, Sriganeshan, V (2013) Precursor B-cell acute lymphoblastic leukemia/lymphoma with L3 morphology, Philadelphia chromosome, MYC gene translocation, and coexpression of TdT and surface light chains: a case report. Case Rep Pathol 2013: pp. 679892
  16. Kansal, R, Deeb, G, Barcos, M, Wetzler, M, Brecher, ML, Block, AW, Stewart, CC (2004) Precursor B lymphoblastic leukemia with surface light chain immunoglobulin restriction: a report of 15 patients. Am J Clin Pathol 121: pp. 512-525 CrossRef
  17. Juskevicius, D, Ruiz, C, Dirnhofer, S, Tzankov, A (2014) Clinical, morphologic, phenotypic, and genetic evidence of cyclin D1-positive diffuse large B-cell lymphomas with CYCLIN D1 gene rearrangements. Am J Surg Pathol 38: pp. 719-727 CrossRef
  18. Lucioni, M, Novara, F, Riboni, R, Fiandrino, G, Nicola, M, Kindl, S, Boveri, E, Jemos, V, Arcaini, L, Zuffardi, O, Paulli, M (2011) CD5(? diffuse large B-cell lymphoma w
• 刊物主题：Pathology; Hematology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1865-5785

文摘

Mantle cell lymphoma is a mature B-cell neoplasm composed of small to medium-sized atypical lymphocytes and has a characteristic t(11;14)(q13;q32) translocation, with a variably aggressive and overall incurable course. More aggressive histologic variants have been described, as well as rare cases of transformation to other large cell lymphomas. Here, we describe a novel case of large cell blastic transformation of mantle cell lymphoma/leukemia at presentation with unusual immunophenotypic and cytogenetic features, most consistent with B-lymphoblastic leukemia. Morphologic findings include sheets of large blasts replacing the bone marrow, as well as occasional small to medium-sized atypical lymphocytes in the background. The blasts express CD19, PAX5, CD10, Cyclin D1, and TdT but are negative for CD5, CD20, and BCL2 by immunophenotyping. Cytogenetic studies show a complex karyotype with t(11;14), monosomy 13, gains of 8q, and MYC gene rearrangement and amplification among other changes. This unique case of blastic TdT-positive B-cell leukemia arising from mantle cell lymphoma may represent transformation with complex cytogenetic abnormalities including “double hit-changes. This distinctive presentation may expand our understanding of the biology behind mantle cell lymphoma progression.